EC number:1.3.1.21
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.3.1.21 |
|---|---|
| Description: | 7-dehydrocholesterol reductase. |
| Alternative Name: |
Sterol Delta(7)-reductase. Delta(7)-sterol reductase. 7-DHC reductase. 7-dehydrocholesterol dehydrogenase/cholesterol oxidase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.1.21 |
| BRENDA Enzyme Link: | BRENDA 1.3.1.21 |
| KEGG Enzyme Link: | KEGG1.3.1.21 |
| BioCyc Enzyme Link: | BioCyc 1.3.1.21 |
| ExPASy Enzyme Link: | ExPASy1.3.1.21 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.1.21 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.1.21 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.1.21 |
| IntEnz Enzyme Link: | IntEnz 1.3.1.21 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.1.21 |
| RHEA:23984 | cholesterol + NADP(+) = cholesta-5,7-dien-3beta-ol + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mutations in the human sterol delta7-reductase gene at 11q12-13 cause Smith-Lemli-Opitz syndrome. | Wassif CA, Maslen C, Kachilele-Linjewile S, Lin D, Linck LM, Connor WE, Steiner RD, Porter FD | 1998 Jul | 9634533 |
| Molecular cloning and expression of the human delta7-sterol reductase. | Moebius FF, Fitzky BU, Lee JN, Paik YK, Glossmann H | 1998 Feb 17 | 9465114 |
| THE INTERMEDIARY ROLE OF DELTA-5,7-CHOLESTADIEN-3-BETA-OL IN CHOLESTEROL BIOSYNTHESIS. | DEMPSEY ME, SEATON JD, SCHROEPFER GJ Jr, TROCKMAN RW | 1964 May | 14189869 |
| Biochemical, phenotypic and neurophysiological characterization of a genetic mouse model of RSH/Smith--Lemli--Opitz syndrome. | Wassif CA, Zhu P, Kratz L, Krakowiak PA, Battaile KP, Weight FF, Grinberg A, Steiner RD, Nwokoro NA, Kelley RI, Stewart RR, Porter FD | 2001 Mar 15 | 11230174 |
| Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue distribution, expression, chromosomal localization, and regulation of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz syndrome-related protein. | Bae SH, Lee JN, Fitzky BU, Seong J, Paik YK | 1999 May 21 | 10329655 |