EC number:1.3.1.22
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.3.1.22 |
|---|---|
| Description: | 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). |
| Alternative Name: |
Cholestenone 5-alpha-reductase. 3-oxo-5-alpha-steroid 4-dehydrogenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.1.22 |
| BRENDA Enzyme Link: | BRENDA 1.3.1.22 |
| KEGG Enzyme Link: | KEGG1.3.1.22 |
| BioCyc Enzyme Link: | BioCyc 1.3.1.22 |
| ExPASy Enzyme Link: | ExPASy1.3.1.22 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.1.22 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.1.22 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.1.22 |
| IntEnz Enzyme Link: | IntEnz 1.3.1.22 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.1.22 |
| RHEA:54384 | a 3-oxo-5alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[CH2;+0:4]-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[CH;+0:4]-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Conservation of function between mammalian and plant steroid 5alpha-reductases. | Li J, Biswas MG, Chao A, Russell DW, Chory J | 1997 Apr 15 | 9108014 |
| GhDET2, a steroid 5alpha-reductase, plays an important role in cotton fiber cell initiation and elongation. | Luo M, Xiao Y, Li X, Lu X, Deng W, Li D, Hou L, Hu M, Li Y, Pei Y | 2007 Aug | 17565582 |
| 5alpha-Reductase activity in Lycopersicon esculentum: cloning and functional characterization of LeDET2 and evidence of the presence of two isoenzymes. | Rosati F, Bardazzi I, De Blasi P, Simi L, Scarpi D, Guarna A, Serio M, Racchi ML, Danza G | 2005 Aug | 15993049 |
| Tissue distribution and kinetic characteristics of rat steroid 5 alpha-reductase isozymes. Evidence for distinct physiological functions. | Normington K, Russell DW | 1992 Sep 25 | 1527072 |
| Biochemical and pharmacogenetic dissection of human steroid 5 alpha-reductase type II. | Makridakis NM, di Salle E, Reichardt JK | 2000 Jul | 10898110 |
| Arabidopsis det2 is defective in the conversion of (24R)-24-methylcholest-4-En-3-one to (24R)-24-methyl-5alpha-cholestan-3-one in brassinosteroid biosynthesis. | Noguchi T, Fujioka S, Takatsuto S, Sakurai A, Yoshida S, Li J, Chory J | 1999 Jul | 10398719 |
| Formation of dolichol from dehydrodolichol is catalyzed by NADPH-dependent reductase localized in microsomes of rat liver. | Sagami H, Kurisaki A, Ogura K | 1993 May 15 | 8486680 |
| RHEA:50820 | 17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = H(+) + NADPH + testosterone |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of 5α-reductase activity and isoenzymes in human abdominal adipose tissues. | Fouad Mansour M, Pelletier M, Tchernof A | 2016 Jul | 26855069 |
| Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer. | Uemura M, Tamura K, Chung S, Honma S, Okuyama A, Nakamura Y, Nakagawa H | 2008 Jan | 17986282 |
| Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases. | Andersson S, Russell DW | 1990 May | 2339109 |
| RHEA:21952 | 5alpha-pregnane-3,20-dione + NADP(+) = H(+) + NADPH + progesterone |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Important roles of the AKR1C2 and SRD5A1 enzymes in progesterone metabolism in endometrial cancer model cell lines. | Sinreih M, Anko M, Zukunft S, Adamski J, Rižner TL | 2015 Jun 5 | 25463305 |
| Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases. | Andersson S, Russell DW | 1990 May | 2339109 |