EC number:1.3.1.38
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.3.1.38 | ||
|---|---|---|---|
| Description: | Trans-2-enoyl-CoA reductase (NADPH). | ||
| Prosite: | PDOC00060; | ||
| PDB: |
|
||
| Cath: | 3.40.50.720; 3.90.180.10; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.1.38 |
| BRENDA Enzyme Link: | BRENDA 1.3.1.38 |
| KEGG Enzyme Link: | KEGG1.3.1.38 |
| BioCyc Enzyme Link: | BioCyc 1.3.1.38 |
| ExPASy Enzyme Link: | ExPASy1.3.1.38 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.1.38 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.1.38 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.1.38 |
| IntEnz Enzyme Link: | IntEnz 1.3.1.38 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.1.38 |
| RHEA:33763 | a (2E)-enoyl CoA + H(+) + NADPH = a 2,3-saturated acyl-CoA + NADP(+) |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[*:5]-[c;H0;+0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[n+;H0:10](-[*:11]):[cH;+0:12]:1>>[*:5]-[C;H0;+0:6]1=[CH;+0:12]-[N;H0;+0:10](-[*:11])-[CH;+0:9]=[CH;+0:8]-[CH2;+0:7]-1.[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Studies on the metabolism of unsaturated fatty acids. IX. Stereochemical studies of the reaction catalyzed by trans-2-enoyl-coenzyme A reductase of Escherichia coli. | Mizugaki M, Nishimaki T, Shiraishi T, Kawaguchi A, Okuda S, Yamanaka H | 1982 Nov | 6759504 |
| Characterization of 2-enoyl thioester reductase from mammals. An ortholog of YBR026p/MRF1'p of the yeast mitochondrial fatty acid synthesis type II. | Miinalainen IJ, Chen ZJ, Torkko JM, Pirilä PL, Sormunen RT, Bergmann U, Qin YM, Hiltunen JK | 2003 May 30 | 12654921 |
| Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs. | Das AK, Uhler MD, Hajra AK | 2000 Aug 11 | 10811639 |
| Structural enzymological studies of 2-enoyl thioester reductase of the human mitochondrial FAS II pathway: new insights into its substrate recognition properties. | Chen ZJ, Pudas R, Sharma S, Smart OS, Juffer AH, Hiltunen JK, Wierenga RK, Haapalainen AM | 2008 Jun 13 | 18479707 |
| Candida tropicalis expresses two mitochondrial 2-enoyl thioester reductases that are able to form both homodimers and heterodimers. | Torkko JM, Koivuranta KT, Kastaniotis AJ, Airenne TT, Glumoff T, Ilves M, Hartig A, Gurvitz A, Hiltunen JK | 2003 Oct 17 | 12890667 |