EC number:1.3.1.48
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.3.1.48 |
|---|---|
| Description: | 15-oxoprostaglandin 13-reductase. |
| Alternative Name: |
Prostaglandin 13-reductase. 15-oxo-Delta(13)-prostaglandin reductase. |
| Cath: | 3.40.50.720; 3.90.180.10; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.1.48 |
| BRENDA Enzyme Link: | BRENDA 1.3.1.48 |
| KEGG Enzyme Link: | KEGG1.3.1.48 |
| BioCyc Enzyme Link: | BioCyc 1.3.1.48 |
| ExPASy Enzyme Link: | ExPASy1.3.1.48 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.1.48 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.1.48 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.1.48 |
| IntEnz Enzyme Link: | IntEnz 1.3.1.48 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.1.48 |
| RHEA:11916 | 13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxo-prostaglandin E2 + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Prostaglandin reductase-3 negatively modulates adipogenesis through regulation of PPARγ activity. | Yu YH, Chang YC, Su TH, Nong JY, Li CC, Chuang LM | 2013 Sep | 23821743 |
| Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2. | Wu YH, Ko TP, Guo RT, Hu SM, Chuang LM, Wang AH | 2008 Nov 12 | 19000823 |
| Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation. | Chou WL, Chuang LM, Chou CC, Wang AH, Lawson JA, FitzGerald GA, Chang ZF | 2007 Jun 22 | 17449869 |
| Identification of dual cyclooxygenase-eicosanoid oxidoreductase inhibitors: NSAIDs that inhibit PG-LX reductase/LTB(4) dehydrogenase. | Clish CB, Sun YP, Serhan CN | 2001 Nov 9 | 11688989 |
| RHEA:11912 | 13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxo-prostaglandin E2 + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Human prostaglandin reductase 1 (PGR1): Substrate specificity, inhibitor analysis and site-directed mutagenesis. | Mesa J, Alsina C, Oppermann U, Parés X, Farrés J, Porté S | 2015 Jun 5 | 25619643 |
| Prostaglandin reductase-3 negatively modulates adipogenesis through regulation of PPARγ activity. | Yu YH, Chang YC, Su TH, Nong JY, Li CC, Chuang LM | 2013 Sep | 23821743 |
| Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2. | Wu YH, Ko TP, Guo RT, Hu SM, Chuang LM, Wang AH | 2008 Nov 12 | 19000823 |
| Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation. | Chou WL, Chuang LM, Chou CC, Wang AH, Lawson JA, FitzGerald GA, Chang ZF | 2007 Jun 22 | 17449869 |