EC number:1.3.1.54
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.3.1.54 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description: | Precorrin-6A reductase. | ||||||||
| Alternative Name: |
Precorrin-6Y:NADP(+) oxidoreductase. Precorrin-6X reductase. | ||||||||
| Prosite: | PDOC51014; | ||||||||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.1.54 |
| BRENDA Enzyme Link: | BRENDA 1.3.1.54 |
| KEGG Enzyme Link: | KEGG1.3.1.54 |
| BioCyc Enzyme Link: | BioCyc 1.3.1.54 |
| ExPASy Enzyme Link: | ExPASy1.3.1.54 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.1.54 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.1.54 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.1.54 |
| IntEnz Enzyme Link: | IntEnz 1.3.1.54 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.1.54 |
| RHEA:23408 | NADP(+) + precorrin-6B = 2 H(+) + NADPH + precorrin-6A |
| RULE(radius=1) | [*:1]-[CH;+0:2]1-[*:3]-[*:4](-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[NH;+0:8]-[*:9])=[*:10]-[CH;+0:11]-1-[*:12].[*:13]-[c;H0;+0:14]1:[cH;+0:15]:[cH;+0:16]:[cH;+0:17]:[n+;H0:18](-[*:19]):[cH;+0:20]:1>>[*:1]-[C;H0;+0:2]1=[C;H0;+0:11](-[*:12])-[*:10]=[*:4](-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[N;H0;+0:8]-[*:9])-[*:3]-1.[*:13]-[C;H0;+0:14]1=[CH;+0:20]-[N;H0;+0:18](-[*:19])-[CH;+0:17]=[CH;+0:16]-[CH2;+0:15]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The biosynthesis of adenosylcobalamin (vitamin B12). | Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC | 2002 Aug | 12195810 |
| Precorrin-6x reductase from Pseudomonas denitrificans: purification and characterization of the enzyme and identification of the structural gene. | Blanche F, Thibaut D, Famechon A, Debussche L, Cameron B, Crouzet J | 1992 Feb | 1732193 |