EC number:1.3.1.70
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.3.1.70 |
|---|---|
| Description: | Delta(14)-sterol reductase. |
| Alternative Name: |
Sterol C14-reductase. C-14 sterol reductase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.1.70 |
| BRENDA Enzyme Link: | BRENDA 1.3.1.70 |
| KEGG Enzyme Link: | KEGG1.3.1.70 |
| BioCyc Enzyme Link: | BioCyc 1.3.1.70 |
| ExPASy Enzyme Link: | ExPASy1.3.1.70 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.1.70 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.1.70 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.1.70 |
| IntEnz Enzyme Link: | IntEnz 1.3.1.70 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.1.70 |
| RHEA:18561 | 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[CH2;+0:4]-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[CH;+0:4]-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Microsomal enzymes of cholesterol biosynthesis from lanosterol. Characterization, solubilization, and partial purification of NADPH-dependent delta 8,14-steroid 14-reductase. | Paik YK, Trzaskos JM, Shafiee A, Gaylor JL | 1984 Nov 10 | 6444198 |
| Autosomal recessive HEM/Greenberg skeletal dysplasia is caused by 3 beta-hydroxysterol delta 14-reductase deficiency due to mutations in the lamin B receptor gene. | Waterham HR, Koster J, Mooyer P, Noort Gv Gv, Kelley RI, Wilcox WR, Wanders RJ, Hennekam RC, Oosterwijk JC | 2003 Apr | 12618959 |
| Cloning and expression of sterol Delta 14-reductase from bovine liver. | Roberti R, Bennati AM, Galli G, Caruso D, Maras B, Aisa C, Beccari T, Della Fazia MA, Servillo G | 2002 Jan | 11784322 |