EC number:1.3.1.72
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.3.1.72 |
|---|---|
| Description: | Delta(24)-sterol reductase. |
| Alternative Name: |
Lanosterol Delta(24)-reductase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.1.72 |
| BRENDA Enzyme Link: | BRENDA 1.3.1.72 |
| KEGG Enzyme Link: | KEGG1.3.1.72 |
| BioCyc Enzyme Link: | BioCyc 1.3.1.72 |
| ExPASy Enzyme Link: | ExPASy1.3.1.72 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.1.72 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.1.72 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.1.72 |
| IntEnz Enzyme Link: | IntEnz 1.3.1.72 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.1.72 |
| RHEA:13685 | 5alpha-cholest-7-en-3beta-ol + NADP(+) = 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The Arabidopsis DIMINUTO/DWARF1 gene encodes a protein involved in steroid synthesis. | Klahre U, Noguchi T, Fujioka S, Takatsuto S, Yokota T, Nomura T, Yoshida S, Chua NH | 1998 Oct | 9761794 |
| Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. | Bae SH, Paik YK | 1997 Sep 1 | 9291139 |
| A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. | Mazein A, Watterson S, Hsieh WY, Griffiths WJ, Ghazal P | 2013 Jul 1 | 23583456 |
| The Arabidopsis dwarf1 mutant is defective in the conversion of 24-methylenecholesterol to campesterol in brassinosteroid biosynthesis. | Choe S, Dilkes BP, Gregory BD, Ross AS, Yuan H, Noguchi T, Fujioka S, Takatsuto S, Tanaka A, Yoshida S, Tax FE, Feldmann KA | 1999 Mar | 10069828 |
| RHEA:36391 | cholesterol + NADP(+) = cholesta-5,24-dien-3beta-ol + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. | Bae SH, Paik YK | 1997 Sep 1 | 9291139 |
| A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. | Mazein A, Watterson S, Hsieh WY, Griffiths WJ, Ghazal P | 2013 Jul 1 | 23583456 |
| The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1). | Zerenturk EJ, Kristiana I, Gill S, Brown AJ | 2012 Sep | 22178193 |
| Inhibition of cholesterol biosynthesis by Delta22-unsaturated phytosterols via competitive inhibition of sterol Delta24-reductase in mammalian cells. | Fernández C, Suárez Y, Ferruelo AJ, Gómez-Coronado D, Lasunción MA | 2002 Aug 15 | 12162789 |
| Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. | Waterham HR, Koster J, Romeijn GJ, Hennekam RC, Vreken P, Andersson HC, FitzPatrick DR, Kelley RI, Wanders RJ | 2001 Oct | 11519011 |
| RHEA:36395 | cholesta-5,7-dien-3beta-ol + NADP(+) = cholesta-5,7,24-trien-3beta-ol + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. | Mazein A, Watterson S, Hsieh WY, Griffiths WJ, Ghazal P | 2013 Jul 1 | 23583456 |
| RHEA:36399 | 5alpha-cholest-8-en-3beta-ol + NADP(+) = 5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. | Bae SH, Paik YK | 1997 Sep 1 | 9291139 |
| A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. | Mazein A, Watterson S, Hsieh WY, Griffiths WJ, Ghazal P | 2013 Jul 1 | 23583456 |
| Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways. | Mitsche MA, McDonald JG, Hobbs HH, Cohen JC | 2015 Jun 26 | 26114596 |