EC number:1.3.1.79
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.3.1.79 |
|---|---|
| Description: | Arogenate dehydrogenase (NAD(P)(+)). |
| Alternative Name: |
Pretyrosine dehydrogenase. Cyclohexadienyl dehydrogenase. Arogenic dehydrogenase. |
| Cath: | 1.10.3660.10; 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.1.79 |
| BRENDA Enzyme Link: | BRENDA 1.3.1.79 |
| KEGG Enzyme Link: | KEGG1.3.1.79 |
| BioCyc Enzyme Link: | BioCyc 1.3.1.79 |
| ExPASy Enzyme Link: | ExPASy1.3.1.79 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.1.79 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.1.79 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.1.79 |
| IntEnz Enzyme Link: | IntEnz 1.3.1.79 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.1.79 |
| RHEA:15417 | L-arogenate + NADP(+) = CO2 + L-tyrosine + NADPH |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1(-[C;H0;+0:3](=[*:4])-[OH;+0:5])-[CH;+0:6]=[CH;+0:7]-[CH;+0:8](-[*:9])-[CH;+0:10]=[CH;+0:11]-1.[*:12]-[n+;H0:13]1:[cH;+0:14]:[cH;+0:15]:[cH;+0:16]:[c;H0;+0:17](-[*:18]):[cH;+0:19]:1>>[*:12]-[N;H0;+0:13]1-[CH;+0:14]=[CH;+0:15]-[CH2;+0:16]-[C;H0;+0:17](-[*:18])=[CH;+0:19]-1.[*:1]-[c;H0;+0:2]1:[cH;+0:6]:[cH;+0:7]:[c;H0;+0:8](-[*:9]):[cH;+0:10]:[cH;+0:11]:1.[*:4]=[C;H0;+0:3]=[O;H0;+0:5] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Variable enzymological patterning in tyrosine biosynthesis as a means of determining natural relatedness among the Pseudomonadaceae. | Byng GS, Whitaker RJ, Gherna RL, Jensen RA | 1980 Oct | 7419490 |
| Biochemical characterization and crystal structure of Synechocystis arogenate dehydrogenase provide insights into catalytic reaction. | Legrand P, Dumas R, Seux M, Rippert P, Ravelli R, Ferrer JL, Matringe M | 2006 Apr | 16615917 |
| A core catalytic domain of the TyrA protein family: arogenate dehydrogenase from Synechocystis. | Bonner CA, Jensen RA, Gander JE, Keyhani NO | 2004 Aug 15 | 15171683 |
| Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of Arabidopsis thaliana. | Rippert P, Matringe M | 2002 Oct | 12354106 |
| Molecular and biochemical characterization of an Arabidopsis thaliana arogenate dehydrogenase with two highly similar and active protein domains. | Rippert P, Matringe M | 2002 Mar | 11905963 |
| RHEA:12256 | L-arogenate + NAD(+) = CO2 + L-tyrosine + NADH |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1(-[C;H0;+0:3](=[*:4])-[OH;+0:5])-[CH;+0:6]=[CH;+0:7]-[CH;+0:8](-[*:9])-[CH;+0:10]=[CH;+0:11]-1.[*:12]-[n+;H0:13]1:[cH;+0:14]:[cH;+0:15]:[cH;+0:16]:[c;H0;+0:17](-[*:18]):[cH;+0:19]:1>>[*:12]-[N;H0;+0:13]1-[CH;+0:14]=[CH;+0:15]-[CH2;+0:16]-[C;H0;+0:17](-[*:18])=[CH;+0:19]-1.[*:1]-[c;H0;+0:2]1:[cH;+0:6]:[cH;+0:7]:[c;H0;+0:8](-[*:9]):[cH;+0:10]:[cH;+0:11]:1.[*:4]=[C;H0;+0:3]=[O;H0;+0:5] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Variable enzymological patterning in tyrosine biosynthesis as a means of determining natural relatedness among the Pseudomonadaceae. | Byng GS, Whitaker RJ, Gherna RL, Jensen RA | 1980 Oct | 7419490 |
| An allosterically insensitive class of cyclohexadienyl dehydrogenase from Zymomonas mobilis. | Zhao G, Xia T, Ingram LO, Jensen RA | 1993 Feb 15 | 7916685 |
| Cyclohexadienyl dehydrogenase from Pseudomonas stutzeri exemplifies a widespread type of tyrosine-pathway dehydrogenase in the TyrA protein family. | Xie G, Bonner CA, Jensen RA | 2000 Jan | 11790331 |