Enzyme

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EC Tree
     1. Oxidoreductases
        1.3 Acting on the CH-CH group of donors
            1.3.1 With NAD+ or NADP+ as acceptor
ID:1.3.1.82
Description:(-)-isopiperitenone reductase.
Prosite: PDOC00060;
PDB:
PDBScop
Cath: 3.40.50.720;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 1.3.1.82
BRENDA Enzyme Link: BRENDA 1.3.1.82
KEGG Enzyme Link: KEGG1.3.1.82
BioCyc Enzyme Link: BioCyc 1.3.1.82
ExPASy Enzyme Link: ExPASy1.3.1.82
EC2PDB Enzyme Link: EC2PDB 1.3.1.82
ExplorEnz Enzyme Link: ExplorEnz 1.3.1.82
PRIAM enzyme-specific profiles Link: PRIAM 1.3.1.82
IntEnz Enzyme Link: IntEnz 1.3.1.82
MEDLINE Enzyme Link: MEDLINE 1.3.1.82
MSA:

1.3.1.82;

Phylogenetic Tree:

1.3.1.82;

Uniprot:
M-CSA:
RHEA:25649 (2R,5R)-isopulegone + NADP(+) = (6R)-isopiperitenone + H(+) + NADPH
RULE(radius=1) [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1
Reaction
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References

TitleAuthorsDatePubMed ID
Metabolism of monoterpenes: demonstration that (+)-cis-isopulegone, not piperitenone, is the key intermediate in the conversion of (-)-isopiperitenone to (+)-pulegone in peppermint (Mentha piperita).Croteau R, Venkatachalam KV1986 Sep3755881
Monoterpene double-bond reductases of the (-)-menthol biosynthetic pathway: isolation and characterization of cDNAs encoding (-)-isopiperitenone reductase and (+)-pulegone reductase of peppermint.Ringer KL, McConkey ME, Davis EM, Rushing GW, Croteau R2003 Oct 113679086