EC number:1.3.1.91
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.3.1.91 |
|---|---|
| Description: | tRNA-dihydrouridine(20) synthase (NAD(P)(+)). |
| Alternative Name: |
tRNA-dihydrouridine synthase 2. |
| Cath: | 1.20.120.1460; 3.20.20.70; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.1.91 |
| BRENDA Enzyme Link: | BRENDA 1.3.1.91 |
| KEGG Enzyme Link: | KEGG1.3.1.91 |
| BioCyc Enzyme Link: | BioCyc 1.3.1.91 |
| ExPASy Enzyme Link: | ExPASy1.3.1.91 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.1.91 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.1.91 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.1.91 |
| IntEnz Enzyme Link: | IntEnz 1.3.1.91 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.1.91 |
| RHEA:53340 | 5,6-dihydrouridine(20) in tRNA + NAD(+) = H(+) + NADH + uridine(20) in tRNA |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH2;+0:3]-[CH2;+0:4]-[C;H0;+0:5](=[*:6])-[NH;+0:7]-[C;H0;+0:8]-1=[*:9].[*:10]-[n+;H0:11]1:[cH;+0:12]:[cH;+0:13]:[cH;+0:14]:[c;H0;+0:15](-[*:16]):[cH;+0:17]:1>>[*:10]-[N;H0;+0:11]1-[CH;+0:12]=[CH;+0:13]-[CH2;+0:14]-[C;H0;+0:15](-[*:16])=[CH;+0:17]-1.[*:1]-[n;H0;+0:2]1:[cH;+0:3]:[cH;+0:4]:[c;H0;+0:5](=[*:6]):[nH;+0:7]:[c;H0;+0:8]:1=[*:9] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mechanism of dihydrouridine synthase 2 from yeast and the importance of modifications for efficient tRNA reduction. | Rider LW, Ottosen MB, Gattis SG, Palfey BA | 2009 Apr 17 | 19139092 |
| A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. | Kato T, Daigo Y, Hayama S, Ishikawa N, Yamabuki T, Ito T, Miyamoto M, Kondo S, Nakamura Y | 2005 Jul 1 | 15994936 |
| The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs. | Xing F, Hiley SL, Hughes TR, Phizicky EM | 2004 Apr 23 | 14970222 |
| A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA. | Xing F, Martzen MR, Phizicky EM | 2002 Mar | 12003496 |
| Molecular basis of dihydrouridine formation on tRNA. | Yu F, Tanaka Y, Yamashita K, Suzuki T, Nakamura A, Hirano N, Suzuki T, Yao M, Tanaka I | 2011 Dec 6 | 22123979 |
| Identification of the tRNA-dihydrouridine synthase family. | Bishop AC, Xu J, Johnson RC, Schimmel P, de Crécy-Lagard V | 2002 Jul 12 | 11983710 |
| RHEA:53336 | 5,6-dihydrouridine(20) in tRNA + NADP(+) = H(+) + NADPH + uridine(20) in tRNA |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH2;+0:3]-[CH2;+0:4]-[C;H0;+0:5](=[*:6])-[NH;+0:7]-[C;H0;+0:8]-1=[*:9].[*:10]-[n+;H0:11]1:[cH;+0:12]:[cH;+0:13]:[cH;+0:14]:[c;H0;+0:15](-[*:16]):[cH;+0:17]:1>>[*:10]-[N;H0;+0:11]1-[CH;+0:12]=[CH;+0:13]-[CH2;+0:14]-[C;H0;+0:15](-[*:16])=[CH;+0:17]-1.[*:1]-[n;H0;+0:2]1:[cH;+0:3]:[cH;+0:4]:[c;H0;+0:5](=[*:6]):[nH;+0:7]:[c;H0;+0:8]:1=[*:9] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mechanism of dihydrouridine synthase 2 from yeast and the importance of modifications for efficient tRNA reduction. | Rider LW, Ottosen MB, Gattis SG, Palfey BA | 2009 Apr 17 | 19139092 |
| A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. | Kato T, Daigo Y, Hayama S, Ishikawa N, Yamabuki T, Ito T, Miyamoto M, Kondo S, Nakamura Y | 2005 Jul 1 | 15994936 |
| The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs. | Xing F, Hiley SL, Hughes TR, Phizicky EM | 2004 Apr 23 | 14970222 |
| A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA. | Xing F, Martzen MR, Phizicky EM | 2002 Mar | 12003496 |
| Molecular basis of dihydrouridine formation on tRNA. | Yu F, Tanaka Y, Yamashita K, Suzuki T, Nakamura A, Hirano N, Suzuki T, Yao M, Tanaka I | 2011 Dec 6 | 22123979 |
| Identification of the tRNA-dihydrouridine synthase family. | Bishop AC, Xu J, Johnson RC, Schimmel P, de Crécy-Lagard V | 2002 Jul 12 | 11983710 |