EC number:1.3.1.94
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.3.1.94 |
|---|---|
| Description: | Polyprenol reductase. |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.1.94 |
| BRENDA Enzyme Link: | BRENDA 1.3.1.94 |
| KEGG Enzyme Link: | KEGG1.3.1.94 |
| BioCyc Enzyme Link: | BioCyc 1.3.1.94 |
| ExPASy Enzyme Link: | ExPASy1.3.1.94 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.1.94 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.1.94 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.1.94 |
| IntEnz Enzyme Link: | IntEnz 1.3.1.94 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.1.94 |
| RHEA:34279 | di-trans,poly-cis-dolichol + NADP(+) = di-trans,cis-polyprenol + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Formation of dolichol from dehydrodolichol is catalyzed by NADPH-dependent reductase localized in microsomes of rat liver. | Sagami H, Kurisaki A, Ogura K | 1993 May 15 | 8486680 |
| SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. | Cantagrel V, Lefeber DJ, Ng BG, Guan Z, Silhavy JL, Bielas SL, Lehle L, Hombauer H, Adamowicz M, Swiezewska E, De Brouwer AP, Blümel P, Sykut-Cegielska J, Houliston S, Swistun D, Ali BR, Dobyns WB, Babovic-Vuksanovic D, van Bokhoven H, Wevers RA, Raetz CR, Freeze HH, Morava E, Al-Gazali L, Gleeson JG | 2010 Jul 23 | 20637498 |