EC number:1.3.1.n3
| ID: | 1.3.1.n3 |
|---|---|
| Description: | Curcumin reductase. |
| Alternative Name: |
NADPH-dependent curcumin/dihydrocurcumin reductase. |
3D structure
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| RHEA:34819 | dihydrocurcumin + NADP(+) = curcumin + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. | Hassaninasab A, Hashimoto Y, Tomita-Yokotani K, Kobayashi M | 2011 Apr 19 | 21467222 |
| RHEA:34815 | 2 NADP(+) + tetrahydrocurcumin = curcumin + 2 H(+) + 2 NADPH |
| RULE(radius=1) | ([*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[*:5]-[CH2;+0:6]-[CH2;+0:7]-[*:8]).[*:9]-[c;H0;+0:10]1:[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:[n+;H0:14](-[*:15]):[cH;+0:16]:1.[*:17]-[n+;H0:18]1:[cH;+0:19]:[cH;+0:20]:[cH;+0:21]:[c;H0;+0:22](-[*:23]):[cH;+0:24]:1>>[*:9]-[C;H0;+0:10]1=[CH;+0:16]-[N;H0;+0:14](-[*:15])-[CH;+0:13]=[CH;+0:12]-[CH2;+0:11]-1.([*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[*:5]-[CH;+0:6]=[CH;+0:7]-[*:8]).[*:17]-[N;H0;+0:18]1-[CH;+0:19]=[CH;+0:20]-[CH2;+0:21]-[C;H0;+0:22](-[*:23])=[CH;+0:24]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. | Hassaninasab A, Hashimoto Y, Tomita-Yokotani K, Kobayashi M | 2011 Apr 19 | 21467222 |
| RHEA:34811 | NADP(+) + tetrahydrocurcumin = dihydrocurcumin + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. | Hassaninasab A, Hashimoto Y, Tomita-Yokotani K, Kobayashi M | 2011 Apr 19 | 21467222 |