EC number:1.3.5.1
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.5 With a quinone or related compound as acceptor |
3D structure
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2BS3;
6B58;
6AWF;
3CIR;
2BS4;
1QLB;
2ACZ;
2WU2;
2WP9;
2WDV;
2WDQ;
3P4R;
1KFY;
3P4P;
5VPN;
3P4Q;
1L0V;
4KX6;
1E7P;
2BS2;
2WS3;
1NEK;
2WU5;
2WDR;
1KF6;
2B76;
4YXD;
4YTP;
3SFE;
3SFD;
3P4S;
3AEG;
3AEF;
3AEE;
3AED;
3AEC;
3AEB;
3AEA;
3AE9;
3AE8;
3AE7;
3AE6;
3AE5;
3AE4;
3AE3;
3AE2;
3AE1;
3ABV;
2WQY;
2H89;
2H88;
2FBW;
1ZP0;
1ZOY;
1YQ4;
1YQ3;
1NEN;
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References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.5.1 |
| BRENDA Enzyme Link: | BRENDA 1.3.5.1 |
| KEGG Enzyme Link: | KEGG1.3.5.1 |
| BioCyc Enzyme Link: | BioCyc 1.3.5.1 |
| ExPASy Enzyme Link: | ExPASy1.3.5.1 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.5.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.5.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.5.1 |
| IntEnz Enzyme Link: | IntEnz 1.3.5.1 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.5.1 |
| RHEA:40523 | a quinone + succinate = a quinol + fumarate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[C;H0;+0:3](-[*:4])-[C;H0;+0:5](=[O;H0;+0:6])-[C;H0;+0:7](-[*:8])=[C;H0;+0:9](-[*:10])-[C;H0;+0:11]-1=[O;H0;+0:12].[*:13]-[CH2;+0:14]-[CH2;+0:15]-[*:16]>>[*:13]-[CH;+0:14]=[CH;+0:15]-[*:16].[*:1]-[c;H0;+0:2]1:[c;H0;+0:11](-[OH;+0:12]):[c;H0;+0:9](-[*:10]):[c;H0;+0:7](-[*:8]):[c;H0;+0:5](-[OH;+0:6]):[c;H0;+0:3]:1-[*:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| One-step purification from Escherichia coli of complex II (succinate: ubiquinone oxidoreductase) associated with succinate-reducible cytochrome b556. | Kita K, Vibat CR, Meinhardt S, Guest JR, Gennis RB | 1989 Feb 15 | 2644269 |
| Function and structure of complex II of the respiratory chain. | Cecchini G | 2003 | 14527321 |
| The four subunits of mitochondrial respiratory complex II are encoded by multiple nuclear genes and targeted to mitochondria in Arabidopsis thaliana. | Figueroa P, Léon G, Elorza A, Holuigue L, Araya A, Jordana X | 2002 Nov | 12374303 |
| RHEA:13713 | a ubiquinone + succinate = a ubiquinol + fumarate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[C;H0;+0:3](-[*:4])-[C;H0;+0:5](=[O;H0;+0:6])-[C;H0;+0:7](-[*:8])=[C;H0;+0:9](-[*:10])-[C;H0;+0:11]-1=[O;H0;+0:12].[*:13]-[CH2;+0:14]-[CH2;+0:15]-[*:16]>>[*:13]-[CH;+0:14]=[CH;+0:15]-[*:16].[*:1]-[c;H0;+0:2]1:[c;H0;+0:3](-[*:4]):[c;H0;+0:5](-[OH;+0:6]):[c;H0;+0:7](-[*:8]):[c;H0;+0:9](-[*:10]):[c;H0;+0:11]:1-[OH;+0:12] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| One-step purification from Escherichia coli of complex II (succinate: ubiquinone oxidoreductase) associated with succinate-reducible cytochrome b556. | Kita K, Vibat CR, Meinhardt S, Guest JR, Gennis RB | 1989 Feb 15 | 2644269 |
| SDHA mutations causing a multisystem mitochondrial disease: novel mutations and genetic overlap with hereditary tumors. | Renkema GH, Wortmann SB, Smeets RJ, Venselaar H, Antoine M, Visser G, Ben-Omran T, van den Heuvel LP, Timmers HJ, Smeitink JA, Rodenburg RJ | 2015 Feb | 24781757 |
| Structure of Escherichia coli succinate:quinone oxidoreductase with an occupied and empty quinone-binding site. | Ruprecht J, Yankovskaya V, Maklashina E, Iwata S, Cecchini G | 2009 Oct 23 | 19710024 |
| 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. | Huang LS, Sun G, Cobessi D, Wang AC, Shen JT, Tung EY, Anderson VE, Berry EA | 2006 Mar 3 | 16371358 |
| Crystal structure of mitochondrial respiratory membrane protein complex II. | Sun F, Huo X, Zhai Y, Wang A, Xu J, Su D, Bartlam M, Rao Z | 2005 Jul 1 | 15989954 |
| Purification and characterization of succinate:menaquinone oxidoreductase from Corynebacterium glutamicum. | Kurokawa T, Sakamoto J | 2005 Aug | 15883782 |
| The quaternary structure of the Saccharomyces cerevisiae succinate dehydrogenase. Homology modeling, cofactor docking, and molecular dynamics simulation studies. | Oyedotun KS, Lemire BD | 2004 Mar 5 | 14672929 |
| Function and structure of complex II of the respiratory chain. | Cecchini G | 2003 | 14527321 |
| The four subunits of mitochondrial respiratory complex II are encoded by multiple nuclear genes and targeted to mitochondria in Arabidopsis thaliana. | Figueroa P, Léon G, Elorza A, Holuigue L, Araya A, Jordana X | 2002 Nov | 12374303 |