EC number:1.3.5.2
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.5 With a quinone or related compound as acceptor |
3D structure
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1EP2;
1EP1;
2DOR;
2BX7;
2BSL;
1OVD;
1JUE;
1JUB;
1JRC;
1JRB;
1JQX;
1JQV;
1DOR;
1UUM;
4ORI;
1UUO;
1F76;
6GJG;
5BOO;
4CQA;
4CQ9;
4CQ8;
6E0B;
5TBO;
5FI8;
5DEL;
4RX0;
4ORM;
3SFK;
3O8A;
3I6R;
3I68;
3I65;
1TV5;
6CJF;
6FMD;
6ET4;
6CJG;
5ZFB;
5ZFA;
5ZF9;
5ZF8;
5ZF7;
5MVD;
5MVC;
5MUT;
5K9D;
5K9C;
5HQE;
5HIN;
5H73;
5H2Z;
4ZMG;
4ZL1;
4YLW;
4RR4;
4RLI;
4RKA;
4RK8;
4OQV;
4LS2;
4LS1;
4LS0;
4JTU;
4JTT;
4JTS;
4JS3;
4JGD;
4IGH;
3ZWT;
3ZWS;
3W7R;
3U2O;
3KVM;
3KVL;
3KVK;
3KVJ;
3G0X;
3G0U;
3FJL;
3FJ6;
3F1Q;
2WV8;
2PRM;
2PRL;
2FQI;
2FPY;
2FPV;
2FPT;
2BXV;
2B0M;
1D3H;
1D3G;
1EP3;
6B8S;
5ZF4;
5UE9;
5KSW;
4XQ6;
2PRH;
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References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.5.2 |
| BRENDA Enzyme Link: | BRENDA 1.3.5.2 |
| KEGG Enzyme Link: | KEGG1.3.5.2 |
| BioCyc Enzyme Link: | BioCyc 1.3.5.2 |
| ExPASy Enzyme Link: | ExPASy1.3.5.2 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.5.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.5.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.5.2 |
| IntEnz Enzyme Link: | IntEnz 1.3.5.2 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.5.2 |
| RHEA:30187 | (S)-dihydroorotate + a quinone = a quinol + orotate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[C;H0;+0:3](-[*:4])-[C;H0;+0:5](=[O;H0;+0:6])-[C;H0;+0:7](-[*:8])=[C;H0;+0:9](-[*:10])-[C;H0;+0:11]-1=[O;H0;+0:12].[*:13]=[C;H0;+0:14]1-[NH;+0:15]-[C;H0;+0:16](=[*:17])-[CH2;+0:18]-[CH;+0:19](-[*:20])-[NH;+0:21]-1>>[*:1]-[c;H0;+0:2]1:[c;H0;+0:11](-[OH;+0:12]):[c;H0;+0:9](-[*:10]):[c;H0;+0:7](-[*:8]):[c;H0;+0:5](-[OH;+0:6]):[c;H0;+0:3]:1-[*:4].[*:13]=[c;H0;+0:14]1:[nH;+0:15]:[c;H0;+0:16](=[*:17]):[cH;+0:18]:[c;H0;+0:19](-[*:20]):[nH;+0:21]:1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase. | Bader B, Knecht W, Fries M, Löffler M | 1998 Aug | 9693067 |
| Purification and properties of the bovine liver mitochondrial dihydroorotate dehydrogenase. | Hines V, Keys LD 3rd, Johnston M | 1986 Aug 25 | 3733756 |
| Mammalian dihydroorotate dehydrogenase: physical and catalytic properties of the primary enzyme. | Forman HJ, Kennedy J | 1978 Nov | 216313 |
| Mechanism of flavin reduction in class 2 dihydroorotate dehydrogenases. | Fagan RL, Nelson MN, Pagano PM, Palfey BA | 2006 Dec 19 | 17154530 |
| Evolutionary implications of the mosaic pyrimidine-biosynthetic pathway in eukaryotes. | Nara T, Hshimoto T, Aoki T | 2000 Oct 31 | 11080587 |
| The activity of Escherichia coli dihydroorotate dehydrogenase is dependent on a conserved loop identified by sequence homology, mutagenesis, and limited proteolysis. | Björnberg O, Grüner AC, Roepstorff P, Jensen KF | 1999 Mar 9 | 10074342 |
| RHEA:28691 | (S)-dihydroorotate + a ubiquinone = a ubiquinol + orotate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[C;H0;+0:3](-[*:4])-[C;H0;+0:5](=[O;H0;+0:6])-[C;H0;+0:7](-[*:8])=[C;H0;+0:9](-[*:10])-[C;H0;+0:11]-1=[O;H0;+0:12].[*:13]=[C;H0;+0:14]1-[NH;+0:15]-[C;H0;+0:16](=[*:17])-[CH2;+0:18]-[CH;+0:19](-[*:20])-[NH;+0:21]-1>>[*:1]-[c;H0;+0:2]1:[c;H0;+0:3](-[*:4]):[c;H0;+0:5](-[OH;+0:6]):[c;H0;+0:7](-[*:8]):[c;H0;+0:9](-[*:10]):[c;H0;+0:11]:1-[OH;+0:12].[*:13]=[c;H0;+0:14]1:[nH;+0:15]:[c;H0;+0:16](=[*:17]):[cH;+0:18]:[c;H0;+0:19](-[*:20]):[nH;+0:21]:1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase. | Bader B, Knecht W, Fries M, Löffler M | 1998 Aug | 9693067 |
| Purification and properties of the bovine liver mitochondrial dihydroorotate dehydrogenase. | Hines V, Keys LD 3rd, Johnston M | 1986 Aug 25 | 3733756 |
| Mammalian dihydroorotate dehydrogenase: physical and catalytic properties of the primary enzyme. | Forman HJ, Kennedy J | 1978 Nov | 216313 |
| Mechanism of flavin reduction in class 2 dihydroorotate dehydrogenases. | Fagan RL, Nelson MN, Pagano PM, Palfey BA | 2006 Dec 19 | 17154530 |
| Evolutionary implications of the mosaic pyrimidine-biosynthetic pathway in eukaryotes. | Nara T, Hshimoto T, Aoki T | 2000 Oct 31 | 11080587 |
| The activity of Escherichia coli dihydroorotate dehydrogenase is dependent on a conserved loop identified by sequence homology, mutagenesis, and limited proteolysis. | Björnberg O, Grüner AC, Roepstorff P, Jensen KF | 1999 Mar 9 | 10074342 |
| RHEA:28687 | (S)-dihydroorotate + ubiquinone-8 = orotate + ubiquinol-8 |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[C;H0;+0:3](-[*:4])-[C;H0;+0:5](=[O;H0;+0:6])-[C;H0;+0:7](-[*:8])=[C;H0;+0:9](-[*:10])-[C;H0;+0:11]-1=[O;H0;+0:12].[*:13]=[C;H0;+0:14]1-[NH;+0:15]-[C;H0;+0:16](=[*:17])-[CH2;+0:18]-[CH;+0:19](-[*:20])-[NH;+0:21]-1>>[*:1]-[c;H0;+0:2]1:[c;H0;+0:3](-[*:4]):[c;H0;+0:5](-[OH;+0:6]):[c;H0;+0:7](-[*:8]):[c;H0;+0:9](-[*:10]):[c;H0;+0:11]:1-[OH;+0:12].[*:13]=[c;H0;+0:14]1:[nH;+0:15]:[c;H0;+0:16](=[*:17]):[cH;+0:18]:[c;H0;+0:19](-[*:20]):[nH;+0:21]:1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |