EC number:1.3.8.1
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.8 With a flavin as acceptor |
| ID: | 1.3.8.1 | ||
|---|---|---|---|
| Description: | Short-chain acyl-CoA dehydrogenase. | ||
| Alternative Name: |
Unsaturated acyl-CoA reductase. Short-chain acyl CoA dehydrogenase. Butyryl dehydrogenase. Butanoyl-CoA dehydrogenase. | ||
| Prosite: | PDOC00070; | ||
| PDB: |
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| Cath: | 1.10.540.10; 1.20.140.10; 2.40.110.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.8.1 |
| BRENDA Enzyme Link: | BRENDA 1.3.8.1 |
| KEGG Enzyme Link: | KEGG1.3.8.1 |
| BioCyc Enzyme Link: | BioCyc 1.3.8.1 |
| ExPASy Enzyme Link: | ExPASy1.3.8.1 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.8.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.8.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.8.1 |
| IntEnz Enzyme Link: | IntEnz 1.3.8.1 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.8.1 |
| RHEA:47196 | a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[*:5]:[c;H0;+0:6]1:[n;H0;+0:7]:[*:8]:[*:9]:[n;H0;+0:10](-[*:11]):[c;H0;+0:12]-1:[n;H0;+0:13]:[*:14].[H+;H0:15]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[*:5]:[c;H0;+0:6]1:[c;H0;+0:12](:[nH;+0:13]:[*:14])-[N;H0;+0:10](-[*:11])-[*:9]:[*:8]-[NH;+0:7]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The protein coded by the PP2216 gene of Pseudomonas putida KT2440 is an acyl-CoA dehydrogenase that oxidises only short-chain aliphatic substrates. | McMahon B, Gallagher ME, Mayhew SG | 2005 Sep 1 | 16024185 |
| Structure and mechanism of action of the acyl-CoA dehydrogenases. | Thorpe C, Kim JJ | 1995 Jun | 7601336 |
| The purification and properties of ox liver short-chain acyl-CoA dehydrogenase. | Shaw L, Engel PC | 1984 Mar 1 | 6712627 |
| Studies on the fatty acid oxidizing system of animal tissues. IV. The prosthetic group of butyryl coenzyme A dehydrogenase. | MAHLER HR | 1954 Jan | 13130522 |
| Studies on the fatty acid oxidizing system of animal tissues. III. Butyryl coenzyme A dehydrogenase. | GREEN DE, MII S, MAHLER HR, BOCK RM | 1954 Jan | 13130521 |
| RHEA:24004 | butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[*:5]:[c;H0;+0:6]1:[n;H0;+0:7]:[*:8]:[*:9]:[n;H0;+0:10](-[*:11]):[c;H0;+0:12]-1:[n;H0;+0:13]:[*:14].[H+;H0:15]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[*:5]:[c;H0;+0:6]1:[c;H0;+0:12](:[nH;+0:13]:[*:14])-[N;H0;+0:10](-[*:11])-[*:9]:[*:8]-[NH;+0:7]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Isolation and expression of a cDNA encoding the precursor for a novel member (ACADSB) of the acyl-CoA dehydrogenase gene family. | Rozen R, Vockley J, Zhou L, Milos R, Willard J, Fu K, Vicanek C, Low-Nang L, Torban E, Fournier B | 1994 Nov 15 | 7698750 |
| Structure and mechanism of action of the acyl-CoA dehydrogenases. | Thorpe C, Kim JJ | 1995 Jun | 7601336 |
| The purification and properties of ox liver short-chain acyl-CoA dehydrogenase. | Shaw L, Engel PC | 1984 Mar 1 | 6712627 |
| Identification and characterization of new long chain acyl-CoA dehydrogenases. | He M, Pei Z, Mohsen AW, Watkins P, Murdoch G, Van Veldhoven PP, Ensenauer R, Vockley J | 2011 Apr | 21237683 |
| Studies on the fatty acid oxidizing system of animal tissues. IV. The prosthetic group of butyryl coenzyme A dehydrogenase. | MAHLER HR | 1954 Jan | 13130522 |
| Studies on the fatty acid oxidizing system of animal tissues. III. Butyryl coenzyme A dehydrogenase. | GREEN DE, MII S, MAHLER HR, BOCK RM | 1954 Jan | 13130521 |