EC number:1.3.98.1
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.98 With other, known, physiological acceptors |
| ID: | 1.3.98.1 | ||
|---|---|---|---|
| Description: | Dihydroorotate oxidase (fumarate). | ||
| Alternative Name: |
Dihydroorotate oxidase. Dihydroorotate dehydrogenase. Dihydoorotic acid dehydrogenase. DHOdehase. DHODase. DHOD. | ||
| Prosite: | PDOC00708; | ||
| PDB: |
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| Cath: | 3.20.20.70; 2.30.26.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.98.1 |
| BRENDA Enzyme Link: | BRENDA 1.3.98.1 |
| KEGG Enzyme Link: | KEGG1.3.98.1 |
| BioCyc Enzyme Link: | BioCyc 1.3.98.1 |
| ExPASy Enzyme Link: | ExPASy1.3.98.1 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.98.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.98.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.98.1 |
| IntEnz Enzyme Link: | IntEnz 1.3.98.1 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.98.1 |
| RHEA:30059 | (S)-dihydroorotate + fumarate = orotate + succinate |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[CH;+0:3]-[*:4].[*:5]=[C;H0;+0:6]1-[NH;+0:7]-[C;H0;+0:8](=[*:9])-[CH2;+0:10]-[CH;+0:11](-[*:12])-[NH;+0:13]-1>>[*:1]-[CH2;+0:2]-[CH2;+0:3]-[*:4].[*:5]=[c;H0;+0:6]1:[nH;+0:7]:[c;H0;+0:8](=[*:9]):[cH;+0:10]:[c;H0;+0:11](-[*:12]):[nH;+0:13]:1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Two different dihydroorotate dehydrogenases in Lactococcus lactis. | Andersen PS, Jansen PJ, Hammer K | 1994 Jul | 8021180 |
| The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function. | Rowland P, Björnberg O, Nielsen FS, Jensen KF, Larsen S | 1998 Jun | 9655329 |
| Purification and characterization of dihydroorotate dehydrogenase A from Lactococcus lactis, crystallization and preliminary X-ray diffraction studies of the enzyme. | Nielsen FS, Rowland P, Larsen S, Jensen KF | 1996 May | 8732756 |
| Mechanistic studies with deuterated dihydroorotates on the dihydroorotate oxidase from Crithidia fasciculata. | Pascal RA Jr, Walsh CT | 1984 Jun 5 | 6087880 |
| Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction. | Inaoka DK, Sakamoto K, Shimizu H, Shiba T, Kurisu G, Nara T, Aoki T, Kita K, Harada S | 2008 Oct 14 | 18808149 |
| Dihydroorotate dehydrogenase from Saccharomyces cerevisiae: spectroscopic investigations with the recombinant enzyme throw light on catalytic properties and metabolism of fumarate analogues. | Zameitat E, Pierik AJ, Zocher K, Löffler M | 2007 Sep | 17617217 |
| Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function. | Nørager S, Arent S, Björnberg O, Ottosen M, Lo Leggio L, Jensen KF, Larsen S | 2003 Aug 1 | 12732650 |
| Characterization of the dihydroorotate dehydrogenase as a soluble fumarate reductase in Trypanosoma cruzi. | Takashima E, Inaoka DK, Osanai A, Nara T, Odaka M, Aoki T, Inaka K, Harada S, Kita K | 2002 Jul | 12106873 |
| A new type of dihydroorotate dehydrogenase, type 1S, from the thermoacidophilic archaeon Sulfolobus solfataricus. | Sørensen G, Dandanell G | 2002 Jun | 12072960 |
| Dihydrooxonate is a substrate of dihydroorotate dehydrogenase (DHOD) providing evidence for involvement of cysteine and serine residues in base catalysis. | Björnberg O, Jordan DB, Palfey BA, Jensen KF | 2001 Jul 15 | 11437361 |
| Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents. | Liu S, Neidhardt EA, Grossman TH, Ocain T, Clardy J | 2000 Jan 15 | 10673429 |