EC number:1.3.99.5
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.3 Acting on the CH-CH group of donors |
| 1.3.99 With unknown physiological acceptors |
| ID: | 1.3.99.5 |
|---|---|
| Description: | 3-oxo-5-alpha-steroid 4-dehydrogenase (acceptor). |
| Alternative Name: |
Steroid 5-alpha-reductase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.3.99.5 |
| BRENDA Enzyme Link: | BRENDA 1.3.99.5 |
| KEGG Enzyme Link: | KEGG1.3.99.5 |
| BioCyc Enzyme Link: | BioCyc 1.3.99.5 |
| ExPASy Enzyme Link: | ExPASy1.3.99.5 |
| EC2PDB Enzyme Link: | EC2PDB 1.3.99.5 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.3.99.5 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.3.99.5 |
| IntEnz Enzyme Link: | IntEnz 1.3.99.5 |
| MEDLINE Enzyme Link: | MEDLINE 1.3.99.5 |
| RHEA:51060 | 5alpha-androst-1-ene-3,17-dione + A = AH2 + androsta-1,4-diene-3,17-dione |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[*:5]>>[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning, sequencing, and expression of the Pseudomonas testosteroni gene encoding 3-oxosteroid delta 1-dehydrogenase. | Plesiat P, Grandguillot M, Harayama S, Vragar S, Michel-Briand Y | 1991 Nov | 1657885 |
| Comamonas testosteroni 3-ketosteroid-delta 4(5 alpha)-dehydrogenase: gene and protein characterization. | Florin C, Köhler T, Grandguillot M, Plesiat P | 1996 Jun | 8655514 |
| RHEA:51048 | 5alpha-androstan-3,17-dione + A = AH2 + androst-4-ene-3,17-dione |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[*:5]>>[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Comamonas testosteroni 3-ketosteroid-delta 4(5 alpha)-dehydrogenase: gene and protein characterization. | Florin C, Köhler T, Grandguillot M, Plesiat P | 1996 Jun | 8655514 |
| Bacterial oxidation of steroids. II. Studies on the enzymatic mechanism of ring A dehydrogenation. | LEVY HR, TALALAY P | 1959 Aug | 13673006 |
| A new bacterial steroid degradation gene cluster in Comamonas testosteroni TA441 which consists of aromatic-compound degradation genes for seco-steroids and 3-ketosteroid dehydrogenase genes. | Horinouchi M, Hayashi T, Yamamoto T, Kudo T | 2003 Aug | 12902225 |
| RHEA:13805 | A + a 3-oxo-5alpha-steroid = a 3-oxo-Delta(4)-steroid + AH2 |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[*:5]>>[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Comamonas testosteroni 3-ketosteroid-delta 4(5 alpha)-dehydrogenase: gene and protein characterization. | Florin C, Köhler T, Grandguillot M, Plesiat P | 1996 Jun | 8655514 |
| A new bacterial steroid degradation gene cluster in Comamonas testosteroni TA441 which consists of aromatic-compound degradation genes for seco-steroids and 3-ketosteroid dehydrogenase genes. | Horinouchi M, Hayashi T, Yamamoto T, Kudo T | 2003 Aug | 12902225 |