EC number:1.4.1.12
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.4 Acting on the CH-NH2 group of donors |
| 1.4.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.4.1.12 |
|---|---|
| Description: | 2,4-diaminopentanoate dehydrogenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.4.1.12 |
| BRENDA Enzyme Link: | BRENDA 1.4.1.12 |
| KEGG Enzyme Link: | KEGG1.4.1.12 |
| BioCyc Enzyme Link: | BioCyc 1.4.1.12 |
| ExPASy Enzyme Link: | ExPASy1.4.1.12 |
| EC2PDB Enzyme Link: | EC2PDB 1.4.1.12 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.4.1.12 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.4.1.12 |
| IntEnz Enzyme Link: | IntEnz 1.4.1.12 |
| MEDLINE Enzyme Link: | MEDLINE 1.4.1.12 |
| RHEA:24196 | (2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) = (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+) |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[NH2;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1.[OH2;+0:13]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:13].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1.[NH3;+0:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| 2,4-diaminopentanoic acid C 4 dehydrogenase. Purification and properties of the protein. | Somack R, Costilow RN | 1973 Jan 25 | 4684685 |
| Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide. | Tsuda Y, Friedmann HC | 1970 Nov 25 | 4394942 |
| A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine. | Fonknechten N, Perret A, Perchat N, Tricot S, Lechaplais C, Vallenet D, Vergne C, Zaparucha A, Le Paslier D, Weissenbach J, Salanoubat M | 2009 May | 19251850 |
| RHEA:24192 | (2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) = (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+) |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[NH2;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1.[OH2;+0:13]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:13].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1.[NH3;+0:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| 2,4-diaminopentanoic acid C 4 dehydrogenase. Purification and properties of the protein. | Somack R, Costilow RN | 1973 Jan 25 | 4684685 |
| Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide. | Tsuda Y, Friedmann HC | 1970 Nov 25 | 4394942 |
| A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine. | Fonknechten N, Perret A, Perchat N, Tricot S, Lechaplais C, Vallenet D, Vergne C, Zaparucha A, Le Paslier D, Weissenbach J, Salanoubat M | 2009 May | 19251850 |