EC number:1.4.1.13

Enzyme

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EC Tree
     1. Oxidoreductases
        1.4 Acting on the CH-NH2 group of donors
            1.4.1 With NAD+ or NADP+ as acceptor
ID:1.4.1.13
Description:Glutamate synthase (NADPH).
Alternative Name: NADPH-glutamate synthase.
NADPH-dependent glutamate synthase.
L-glutamate synthetase.
L-glutamate synthase.
GOGAT.
Glutamine-ketoglutaric aminotransferase.
Glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP).
Glutamate synthetase (NADP).
Glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase.
Prosite: PDOC00406;
PDB:
PDBScop
2VDC 8056845; 8056846; 8056847; 8056848; 8056849; 8056850; 8056845; 8056846; 8056847; 8056848; 8056849; 8056850; 8056845; 8056846; 8056847; 8056848; 8056849; 8056850; 8056845; 8056846; 8056847; 8056848; 8056849; 8056850; 8056845; 8056846; 8056847; 8056848; 8056849; 8056850; 8056845; 8056846; 8056847; 8056848; 8056849; 8056850;
1EA0 8056845; 8056846; 8056847; 8056848; 8056849; 8056850; 8056845; 8056846; 8056847; 8056848; 8056849; 8056850;
1XFG 8029469; 8041848; 8029469; 8041848;
1XFF 8029469; 8041848; 8029469; 8041848;
3OOJ 8020613; 8029469; 8032993; 8041848; 8052796; 8020613; 8029469; 8032993; 8041848; 8052796; 8020613; 8029469; 8032993; 8041848; 8052796; 8020613; 8029469; 8032993; 8041848; 8052796; 8020613; 8029469; 8032993; 8041848; 8052796; 8020613; 8029469; 8032993; 8041848; 8052796; 8020613; 8029469; 8032993; 8041848; 8052796; 8020613; 8029469; 8032993; 8041848; 8052796;
 » show all
Cath: 3.20.20.70; 3.60.20.10; 2.160.20.60;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.4.1.13
BRENDA Enzyme Link: BRENDA 1.4.1.13
KEGG Enzyme Link: KEGG1.4.1.13
BioCyc Enzyme Link: BioCyc 1.4.1.13
ExPASy Enzyme Link: ExPASy1.4.1.13
EC2PDB Enzyme Link: EC2PDB 1.4.1.13
ExplorEnz Enzyme Link: ExplorEnz 1.4.1.13
PRIAM enzyme-specific profiles Link: PRIAM 1.4.1.13
IntEnz Enzyme Link: IntEnz 1.4.1.13
MEDLINE Enzyme Link: MEDLINE 1.4.1.13

EC number:1.4.1.13

MSA:

1.4.1.13;
Phylogenetic Tree:

1.4.1.13;
Uniprot:
M-CSA:
RHEA:15501 2 L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + L-glutamine + NADPH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[NH2;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1.[*:13]=[C;H0;+0:14](-[*:15])-[OH;+0:16]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:16].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1.[*:13]=[C;H0;+0:14](-[*:15])-[NH2;+0:4]
Reaction
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References

TitleAuthorsDatePubMed ID
Synthesis of glutamate in Aerobacter aerogenes by a hitherto unknown route.Tempest DW, Meers JL, Brown CM1970 Apr5420057
Glutamate synthase from Escherichia coli. An iron-sulfide flavoprotein.Miller RE, Stadtman ER1972 Nov 254565085
Determination of the midpoint potential of the FAD and FMN flavin cofactors and of the 3Fe-4S cluster of glutamate synthase.Ravasio S, Curti B, Vanoni MA2001 May 811331018
Glutamate synthase: a complex iron-sulfur flavoprotein.Vanoni MA, Curti B1999 Apr10357231