EC number:1.4.1.16
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.4 Acting on the CH-NH2 group of donors |
| 1.4.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.4.1.16 |
|---|---|
| Description: | Diaminopimelate dehydrogenase. |
| Alternative Name: |
Meso-diaminopimelate D-dehydrogenase. |
| Cath: | 3.30.360.10; 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.4.1.16 |
| BRENDA Enzyme Link: | BRENDA 1.4.1.16 |
| KEGG Enzyme Link: | KEGG1.4.1.16 |
| BioCyc Enzyme Link: | BioCyc 1.4.1.16 |
| ExPASy Enzyme Link: | ExPASy1.4.1.16 |
| EC2PDB Enzyme Link: | EC2PDB 1.4.1.16 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.4.1.16 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.4.1.16 |
| IntEnz Enzyme Link: | IntEnz 1.4.1.16 |
| MEDLINE Enzyme Link: | MEDLINE 1.4.1.16 |
| RHEA:13561 | H2O + meso-2,6-diaminopimelate + NADP(+) = H(+) + L-2-amino-6-oxopimelate + NADPH + NH4(+) |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[NH2;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1.[OH2;+0:13]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:13].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1.[NH3;+0:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Substrate and inhibitor binding sites in Corynebacterium glutamicum diaminopimelate dehydrogenase. | Scapin G, Cirilli M, Reddy SG, Gao Y, Vederas JC, Blanchard JS | 1998 Mar 10 | 9521647 |
| Expression, purification, and crystallization of meso-diaminopimelate dehydrogenase from Corynebacterium glutamicum. | Reddy SG, Scapin G, Blanchard JS | 1996 Aug | 8865347 |
| Meso-alpha,epsilon-diaminopimelate D-dehydrogenase: distribution and the reaction product. | Misono H, Togawa H, Yamamoto T, Soda K | 1979 Jan | 762012 |
| Properties of meso-alpha,epsilon-diaminopimelate D-dehydrogenase from Bacillus sphaericus. | Misono H, Soda K | 1980 Nov 25 | 7430138 |
| Highly stable meso-diaminopimelate dehydrogenase from an Ureibacillus thermosphaericus strain A1 isolated from a Japanese compost: purification, characterization and sequencing. | Akita H, Fujino Y, Doi K, Ohshima T | 2011 Nov 25 | 22117688 |
| Dual diaminopimelate biosynthesis pathways in Bacteroides fragilis and Clostridium thermocellum. | Hudson AO, Klartag A, Gilvarg C, Dobson RC, Marques FG, Leustek T | 2011 Sep | 21616177 |