EC number:1.4.1.17
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.4 Acting on the CH-NH2 group of donors |
| 1.4.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.4.1.17 |
|---|---|
| Description: | N-methylalanine dehydrogenase. |
| Cath: | 1.10.1530.10; 3.30.1370.60; 3.30.60.50; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.4.1.17 |
| BRENDA Enzyme Link: | BRENDA 1.4.1.17 |
| KEGG Enzyme Link: | KEGG1.4.1.17 |
| BioCyc Enzyme Link: | BioCyc 1.4.1.17 |
| ExPASy Enzyme Link: | ExPASy1.4.1.17 |
| EC2PDB Enzyme Link: | EC2PDB 1.4.1.17 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.4.1.17 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.4.1.17 |
| IntEnz Enzyme Link: | IntEnz 1.4.1.17 |
| MEDLINE Enzyme Link: | MEDLINE 1.4.1.17 |
| RHEA:21768 | H2O + N-methyl-L-alanine + NADP(+) = H(+) + methylamine + NADPH + pyruvate |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[NH;+0:4]-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1.[OH2;+0:14]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:14].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1.[*:5]-[NH2;+0:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structures of Delta1-piperideine-2-carboxylate/Delta1-pyrroline-2-carboxylate reductase belonging to a new family of NAD(P)H-dependent oxidoreductases: conformational change, substrate recognition, and stereochemistry of the reaction. | Goto M, Muramatsu H, Mihara H, Kurihara T, Esaki N, Omi R, Miyahara I, Hirotsu K | 2005 Dec 9 | 16192274 |
| The putative malate/lactate dehydrogenase from Pseudomonas putida is an NADPH-dependent delta1-piperideine-2-carboxylate/delta1-pyrroline-2-carboxylate reductase involved in the catabolism of D-lysine and D-proline. | Muramatsu H, Mihara H, Kakutani R, Yasuda M, Ueda M, Kurihara T, Esaki N | 2005 Feb 18 | 15561717 |
| Purification and characterization of N-methylalanine dehydrogenase. | Lin MC, Wagner C | 1975 May 25 | 236301 |
| N-methyl-L-amino acid dehydrogenase from Pseudomonas putida. A novel member of an unusual NAD(P)-dependent oxidoreductase superfamily. | Mihara H, Muramatsu H, Kakutani R, Yasuda M, Ueda M, Kurihara T, Esaki N | 2005 Mar | 15720386 |