EC number:1.4.1.4
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.4 Acting on the CH-NH2 group of donors |
| 1.4.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.4.1.4 | ||
|---|---|---|---|
| Description: | Glutamate dehydrogenase (NADP(+)). | ||
| Alternative Name: |
Glutamic dehydrogenase. | ||
| Prosite: | PDOC00071; | ||
| PDB: |
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| Cath: | 1.10.285.10; 3.20.20.70; 3.40.50.720; 3.60.20.10; 2.160.20.60; 3.40.50.10860; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.4.1.4 |
| BRENDA Enzyme Link: | BRENDA 1.4.1.4 |
| KEGG Enzyme Link: | KEGG1.4.1.4 |
| BioCyc Enzyme Link: | BioCyc 1.4.1.4 |
| ExPASy Enzyme Link: | ExPASy1.4.1.4 |
| EC2PDB Enzyme Link: | EC2PDB 1.4.1.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.4.1.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.4.1.4 |
| IntEnz Enzyme Link: | IntEnz 1.4.1.4 |
| MEDLINE Enzyme Link: | MEDLINE 1.4.1.4 |
| RHEA:11612 | H2O + L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + NADPH + NH4(+) |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[NH2;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1.[OH2;+0:13]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:13].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1.[NH3;+0:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Synthesis of glutamate in Aerobacter aerogenes by a hitherto unknown route. | Tempest DW, Meers JL, Brown CM | 1970 Apr | 5420057 |
| Glutamate synthase from Escherichia coli. An iron-sulfide flavoprotein. | Miller RE, Stadtman ER | 1972 Nov 25 | 4565085 |
| Determination of the midpoint potential of the FAD and FMN flavin cofactors and of the 3Fe-4S cluster of glutamate synthase. | Ravasio S, Curti B, Vanoni MA | 2001 May 8 | 11331018 |
| Glutamate synthase: a complex iron-sulfur flavoprotein. | Vanoni MA, Curti B | 1999 Apr | 10357231 |