EC number:1.4.1.9
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.4 Acting on the CH-NH2 group of donors |
| 1.4.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.4.1.9 | ||
|---|---|---|---|
| Description: | Leucine dehydrogenase. | ||
| Alternative Name: |
LeuDH. | ||
| Prosite: | PDOC00071; | ||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.4.1.9 |
| BRENDA Enzyme Link: | BRENDA 1.4.1.9 |
| KEGG Enzyme Link: | KEGG1.4.1.9 |
| BioCyc Enzyme Link: | BioCyc 1.4.1.9 |
| ExPASy Enzyme Link: | ExPASy1.4.1.9 |
| EC2PDB Enzyme Link: | EC2PDB 1.4.1.9 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.4.1.9 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.4.1.9 |
| IntEnz Enzyme Link: | IntEnz 1.4.1.9 |
| MEDLINE Enzyme Link: | MEDLINE 1.4.1.9 |
| RHEA:12220 | H2O + L-leucine + NAD(+) = 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+) |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[NH2;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1.[OH2;+0:13]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:13].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1.[NH3;+0:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning, sequencing and overexpression of the leucine dehydrogenase gene from Bacillus cereus. | Stoyan T, Recktenwald A, Kula MR | 1997 Apr 4 | 9188201 |
| Gene cloning, purification, and characterization of thermostable and halophilic leucine dehydrogenase from a halophilic thermophile, Bacillus licheniformis TSN9. | Nagata S, Bakthavatsalam S, Galkin AG, Asada H, Sakai S, Esaki N, Soda K, Ohshima T, Nagasaki S, Misono H | 1995 Dec | 8597545 |
| The purification, characterization, cloning and sequencing of the gene for a halostable and thermostable leucine dehydrogenase from Thermoactinomyces intermedius. | Ohshima T, Nishida N, Bakthavatsalam S, Kataoka K, Takada H, Yoshimura T, Esaki N, Soda K | 1994 Jun 1 | 8020469 |
| Gene cloning and sequence determination of leucine dehydrogenase from Bacillus stearothermophilus and structural comparison with other NAD(P)+-dependent dehydrogenases. | Nagata S, Tanizawa K, Esaki N, Sakamoto Y, Ohshima T, Tanaka H, Soda K | 1988 Dec 13 | 3069133 |