EC number:1.5.1.10

Enzyme

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     1. Oxidoreductases
        1.5 Acting on the CH-NH group of donors
            1.5.1 With NAD+ or NADP+ as acceptor
ID:1.5.1.10
Description:Saccharopine dehydrogenase (NADP(+), L-glutamate-forming).
Alternative Name: Saccharopine reductase.
Aminoadipic semialdehyde-glutamic reductase.
Aminoadipic semialdehyde-glutamate reductase.
Aminoadipate semialdehyde-glutamate reductase.
Cath: 1.10.1870.10; 3.30.360.10; 3.40.50.720;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.5.1.10
BRENDA Enzyme Link: BRENDA 1.5.1.10
KEGG Enzyme Link: KEGG1.5.1.10
BioCyc Enzyme Link: BioCyc 1.5.1.10
ExPASy Enzyme Link: ExPASy1.5.1.10
EC2PDB Enzyme Link: EC2PDB 1.5.1.10
ExplorEnz Enzyme Link: ExplorEnz 1.5.1.10
PRIAM enzyme-specific profiles Link: PRIAM 1.5.1.10
IntEnz Enzyme Link: IntEnz 1.5.1.10
MEDLINE Enzyme Link: MEDLINE 1.5.1.10

EC number:1.5.1.10

MSA:

1.5.1.10;
Phylogenetic Tree:

1.5.1.10;
Uniprot:
M-CSA:
RHEA:10020 H2O + L-saccharopine + NADP(+) = (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH
RULE(radius=1) [*:1]-[NH;+0:2]-[CH2;+0:3]-[*:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1.[OH2;+0:13]>>[*:4]-[CH;+0:3]=[O;H0;+0:13].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1.[*:1]-[NH2;+0:2]
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References

TitleAuthorsDatePubMed ID
Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. 3. Aminoadipic semialdehyde-glutamate reductase.Jones EE, Broquist HP1966 Jul 254380448
Crystal structure of saccharopine reductase from Magnaporthe grisea, an enzyme of the alpha-aminoadipate pathway of lysine biosynthesis.Johansson E, Steffens JJ, Lindqvist Y, Schneider G2000 Oct 1511080625