EC number:1.5.1.15
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.5 Acting on the CH-NH group of donors |
| 1.5.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.5.1.15 | ||
|---|---|---|---|
| Description: | Methylenetetrahydrofolate dehydrogenase (NAD(+)). | ||
| Prosite: | PDOC00616; | ||
| PDB: |
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| Cath: | 3.40.50.720; 3.40.50.10860; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.5.1.15 |
| BRENDA Enzyme Link: | BRENDA 1.5.1.15 |
| KEGG Enzyme Link: | KEGG1.5.1.15 |
| BioCyc Enzyme Link: | BioCyc 1.5.1.15 |
| ExPASy Enzyme Link: | ExPASy1.5.1.15 |
| EC2PDB Enzyme Link: | EC2PDB 1.5.1.15 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.5.1.15 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.5.1.15 |
| IntEnz Enzyme Link: | IntEnz 1.5.1.15 |
| MEDLINE Enzyme Link: | MEDLINE 1.5.1.15 |
| RHEA:22892 | (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[N;H0;+0:3](-[*:4])-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[CH;+0:2]=[N+;H0:3](-[*:4])-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of nicotinamide adenine dinucleotide-dependent methylenetetrahydrofolate dehydrogenase from Clostridium formicoaceticum. | Moore MR, O'Brien WE, Ljungdahl LG | 1974 Aug 25 | 4153026 |
| Mammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissues. | Bolusani S, Young BA, Cole NA, Tibbetts AS, Momb J, Bryant JD, Solmonson A, Appling DR | 2011 Feb 18 | 21163947 |
| The X-ray structure of the NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase from Saccharomyces cerevisiae. | Monzingo AF, Breksa A, Ernst S, Appling DR, Robertus JD | 2000 Jul | 10933503 |