EC number:1.5.1.25
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.5 Acting on the CH-NH group of donors |
| 1.5.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.5.1.25 |
|---|---|
| Description: | Thiomorpholine-carboxylate dehydrogenase. |
| Alternative Name: |
Ketimine reductase. |
| Cath: | 3.30.1780.10; 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.5.1.25 |
| BRENDA Enzyme Link: | BRENDA 1.5.1.25 |
| KEGG Enzyme Link: | KEGG1.5.1.25 |
| BioCyc Enzyme Link: | BioCyc 1.5.1.25 |
| ExPASy Enzyme Link: | ExPASy1.5.1.25 |
| EC2PDB Enzyme Link: | EC2PDB 1.5.1.25 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.5.1.25 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.5.1.25 |
| IntEnz Enzyme Link: | IntEnz 1.5.1.25 |
| MEDLINE Enzyme Link: | MEDLINE 1.5.1.25 |
| RHEA:12504 | NAD(+) + thiomorpholine-3-carboxylate = 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[NH;+0:4]-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[N;H0;+0:4]-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of a ketimine-reducing enzyme. | Nardini M, Ricci G, Caccuri AM, Solinas SP, Vesci L, Cavallini D | 1988 May 2 | 3371353 |
| Mammalian forebrain ketimine reductase identified as μ-crystallin; potential regulation by thyroid hormones. | Hallen A, Cooper AJ, Jamie JF, Haynes PA, Willows RD | 2011 Aug | 21332720 |
| RHEA:12500 | NADP(+) + thiomorpholine-3-carboxylate = 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[NH;+0:4]-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[N;H0;+0:4]-[*:5].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of a ketimine-reducing enzyme. | Nardini M, Ricci G, Caccuri AM, Solinas SP, Vesci L, Cavallini D | 1988 May 2 | 3371353 |
| Mammalian forebrain ketimine reductase identified as μ-crystallin; potential regulation by thyroid hormones. | Hallen A, Cooper AJ, Jamie JF, Haynes PA, Willows RD | 2011 Aug | 21332720 |