EC number:1.5.1.34
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.5 Acting on the CH-NH group of donors |
| 1.5.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.5.1.34 | ||
|---|---|---|---|
| Description: | 6,7-dihydropteridine reductase. | ||
| Alternative Name: |
NADPH-specific dihydropteridine reductase. NADPH-dihydropteridine reductase. NADH-dihydropteridine reductase. NAD(P)H(2):6,7-dihydropteridine oxidoreductase. Dihydropteridine reductase (NADH). Dihydropteridine reductase. Dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase. DHPR. 6,7-dihydropteridine:NAD(P)H oxidoreductase. | ||
| Prosite: | PDOC00060; | ||
| PDB: |
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| Cath: | 1.10.800.10; 3.30.70.260; 3.40.109.10; 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.5.1.34 |
| BRENDA Enzyme Link: | BRENDA 1.5.1.34 |
| KEGG Enzyme Link: | KEGG1.5.1.34 |
| BioCyc Enzyme Link: | BioCyc 1.5.1.34 |
| ExPASy Enzyme Link: | ExPASy1.5.1.34 |
| EC2PDB Enzyme Link: | EC2PDB 1.5.1.34 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.5.1.34 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.5.1.34 |
| IntEnz Enzyme Link: | IntEnz 1.5.1.34 |
| MEDLINE Enzyme Link: | MEDLINE 1.5.1.34 |
| RHEA:17865 | 5,6,7,8-tetrahydropteridine + NADP(+) = 6,7-dihydropteridine + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]:[c;H0;+0:10]1:[c;H0;+0:11](:[*:12])-[NH;+0:13]-[*:14]-[*:15]-[NH;+0:16]-1>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]:[c;H0;+0:10]1:[c;H0;+0:11](:[*:12])=[N;H0;+0:13]-[*:14]-[*:15]-[N;H0;+0:16]=1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Dihydropteridine reductase from bovine liver. Purification, crystallization, and isolation of a binary complex with NADH. | Hasegawa H | 1977 Jan | 191436 |
| RHEA:17869 | 5,6,7,8-tetrahydropteridine + NAD(+) = 6,7-dihydropteridine + H(+) + NADH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]:[c;H0;+0:10]1:[c;H0;+0:11](:[*:12])-[NH;+0:13]-[*:14]-[*:15]-[NH;+0:16]-1>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]:[c;H0;+0:10]1:[c;H0;+0:11](:[*:12])=[N;H0;+0:13]-[*:14]-[*:15]-[N;H0;+0:16]=1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Dihydropteridine reductase. Investigation of the specificity for quinoid dihydropteridine and the inhibition by 2,4-diaminopteridines. | Lind KE | 1972 Feb | 4402916 |
| A new enzyme, NADPH-dihydropteridine reductase in bovine liver. | Nakanishi N, Hasegawa H, Watabe S | 1977 Mar | 16875 |
| RHEA:32247 | (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) = (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[c;H0;+0:10]1:[nH;+0:11]:[c;H0;+0:12](-[*:13]):[n;H0;+0:14]:[c;H0;+0:15](-[*:16]):[c;H0;+0:17]:1-[NH;+0:18]-[*:19]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10]1-[N;H0;+0:11]=[C;H0;+0:12](-[*:13])-[N;H0;+0:14]=[C;H0;+0:15](-[*:16])-[C;H0;+0:17]-1=[N;H0;+0:18]-[*:19] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Dihydropteridine reductase. Investigation of the specificity for quinoid dihydropteridine and the inhibition by 2,4-diaminopteridines. | Lind KE | 1972 Feb | 4402916 |
| Dihydropteridine reductase from bovine liver. Purification, crystallization, and isolation of a binary complex with NADH. | Hasegawa H | 1977 Jan | 191436 |
| A new enzyme, NADPH-dihydropteridine reductase in bovine liver. | Nakanishi N, Hasegawa H, Watabe S | 1977 Mar | 16875 |
| RHEA:32251 | (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) = (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[c;H0;+0:10]1:[nH;+0:11]:[c;H0;+0:12](-[*:13]):[n;H0;+0:14]:[c;H0;+0:15](-[*:16]):[c;H0;+0:17]:1-[NH;+0:18]-[*:19]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]=[C;H0;+0:10]1-[N;H0;+0:11]=[C;H0;+0:12](-[*:13])-[N;H0;+0:14]=[C;H0;+0:15](-[*:16])-[C;H0;+0:17]-1=[N;H0;+0:18]-[*:19] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Dihydropteridine reductase. Investigation of the specificity for quinoid dihydropteridine and the inhibition by 2,4-diaminopteridines. | Lind KE | 1972 Feb | 4402916 |
| Dihydropteridine reductase from bovine liver. Purification, crystallization, and isolation of a binary complex with NADH. | Hasegawa H | 1977 Jan | 191436 |
| A new enzyme, NADPH-dihydropteridine reductase in bovine liver. | Nakanishi N, Hasegawa H, Watabe S | 1977 Mar | 16875 |