EC number:1.5.1.39
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.5 Acting on the CH-NH group of donors |
| 1.5.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.5.1.39 |
|---|---|
| Description: | FMN reductase (NAD(P)H). |
| Cath: | 3.40.109.10; 3.40.50.360; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.5.1.39 |
| BRENDA Enzyme Link: | BRENDA 1.5.1.39 |
| KEGG Enzyme Link: | KEGG1.5.1.39 |
| BioCyc Enzyme Link: | BioCyc 1.5.1.39 |
| ExPASy Enzyme Link: | ExPASy1.5.1.39 |
| EC2PDB Enzyme Link: | EC2PDB 1.5.1.39 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.5.1.39 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.5.1.39 |
| IntEnz Enzyme Link: | IntEnz 1.5.1.39 |
| MEDLINE Enzyme Link: | MEDLINE 1.5.1.39 |
| RHEA:21624 | FMNH2 + NADP(+) = FMN + 2 H(+) + NADPH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]:[nH;+0:10]:[c;H0;+0:11]1:[c;H0;+0:12](:[*:13])-[NH;+0:14]-[*:15]:[*:16]-[N;H0;+0:17]-1-[*:18]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]:[n;H0;+0:10]:[c;H0;+0:11]1:[n;H0;+0:17](-[*:18]):[*:16]:[*:15]:[n;H0;+0:14]:[c;H0;+0:12]-1:[*:13] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of NfrA1, a Bacillus subtilis nitro/flavin reductase capable of interacting with the bacterial luciferase. | Zenno S, Kobori T, Tanokura M, Saigo K | 1998 Oct | 9836433 |
| Mechanism of reduced flavin transfer from Vibrio harveyi NADPH-FMN oxidoreductase to luciferase. | Lei B, Tu SC | 1998 Oct 13 | 9772191 |
| Vibrio harveyi NADPH:FMN oxidoreductase: preparation and characterization of the apoenzyme and monomer-dimer equilibrium. | Liu M, Lei B, Ding Q, Lee JC, Tu SC | 1997 Jan 1 | 8990272 |
| Flavin reductase P: structure of a dimeric enzyme that reduces flavin. | Tanner JJ, Lei B, Tu SC, Krause KL | 1996 Oct 22 | 8885832 |
| Purification and properties of the NADH and NADPH specific FMN oxidoreductases from Beneckea harveyi. | Jablonski E, DeLuca M | 1977 Jun 28 | 880288 |
| Vibrio harveyi NADPH-flavin oxidoreductase: cloning, sequencing and overexpression of the gene and purification and characterization of the cloned enzyme. | Lei B, Liu M, Huang S, Tu SC | 1994 Jun | 8206832 |
| Specificities and properties of three reduced pyridine nucleotide-flavin mononucleotide reductases coupling to bacterial luciferase. | Watanabe H, Hastings JW | 1982 May 14 | 6981058 |
| Studies of the control of luminescence in Beneckea harveyi: properties of the NADH and NADPH:FMN oxidoreductases. | Jablonski E, DeLuca M | 1978 Feb 21 | 23827 |
| Structure and function of YcnD from Bacillus subtilis, a flavin-containing oxidoreductase. | Morokutti A, Lyskowski A, Sollner S, Pointner E, Fitzpatrick TB, Kratky C, Gruber K, Macheroux P | 2005 Oct 25 | 16229462 |
| Identification of NADH-specific and NADPH-specific FMN reductases in Beneckea harveyi. | Gerlo E, Charlier J | 1975 Sep 15 | 1175652 |
| Characterization of a two-component alkanesulfonate monooxygenase from Escherichia coli. | Eichhorn E, van der Ploeg JR, Leisinger T | 1999 Sep 17 | 10480865 |
| RHEA:21620 | FMNH2 + NAD(+) = FMN + 2 H(+) + NADH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]:[nH;+0:10]:[c;H0;+0:11]1:[c;H0;+0:12](:[*:13])-[NH;+0:14]-[*:15]:[*:16]-[N;H0;+0:17]-1-[*:18]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]:[n;H0;+0:10]:[c;H0;+0:11]1:[n;H0;+0:17](-[*:18]):[*:16]:[*:15]:[n;H0;+0:14]:[c;H0;+0:12]-1:[*:13] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning, sequencing, and analysis of a gene cluster from Chelatobacter heintzii ATCC 29600 encoding nitrilotriacetate monooxygenase and NADH:flavin mononucleotide oxidoreductase. | Xu Y, Mortimer MW, Fisher TS, Kahn ML, Brockman FJ, Xun L | 1997 Feb | 9023192 |
| Cloning and nucleotide sequence of the gene for NADH:FMN oxidoreductase from Vibrio harveyi. | Izumoto Y, Mori T, Yamamoto K | 1994 Apr 28 | 8167139 |
| Specificities and properties of three reduced pyridine nucleotide-flavin mononucleotide reductases coupling to bacterial luciferase. | Watanabe H, Hastings JW | 1982 May 14 | 6981058 |
| Flavin mononucleotide reductase of luminous bacteria. | Duane W, Hastings JW | 1975 Jan 31 | 47604 |
| Catalysis of a flavoenzyme-mediated amide hydrolysis. | Mukherjee T, Zhang Y, Abdelwahed S, Ealick SE, Begley TP | 2010 Apr 28 | 20369853 |
| Purification and characterization of a two-component monooxygenase that hydroxylates nitrilotriacetate from "Chelatobacter" strain ATCC 29600. | Uetz T, Schneider R, Snozzi M, Egli T | 1992 Feb | 1735711 |
| Structure and function of YcnD from Bacillus subtilis, a flavin-containing oxidoreductase. | Morokutti A, Lyskowski A, Sollner S, Pointner E, Fitzpatrick TB, Kratky C, Gruber K, Macheroux P | 2005 Oct 25 | 16229462 |
| Identification of NADH-specific and NADPH-specific FMN reductases in Beneckea harveyi. | Gerlo E, Charlier J | 1975 Sep 15 | 1175652 |