EC number:1.5.1.41
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.5 Acting on the CH-NH group of donors |
| 1.5.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.5.1.41 |
|---|---|
| Description: | Riboflavin reductase (NAD(P)H). |
| Alternative Name: |
Riboflavine mononucleotide reductase. Riboflavin mononucleotide reductase. NAD(P)H-dependent FMN reductase. NAD(P)H(2) dehydrogenase (FMN). Flavine mononucleotide reductase. Flavin mononucleotide reductase. |
| Cath: | 3.40.50.80; 2.40.30.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.5.1.41 |
| BRENDA Enzyme Link: | BRENDA 1.5.1.41 |
| KEGG Enzyme Link: | KEGG1.5.1.41 |
| BioCyc Enzyme Link: | BioCyc 1.5.1.41 |
| ExPASy Enzyme Link: | ExPASy1.5.1.41 |
| EC2PDB Enzyme Link: | EC2PDB 1.5.1.41 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.5.1.41 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.5.1.41 |
| IntEnz Enzyme Link: | IntEnz 1.5.1.41 |
| MEDLINE Enzyme Link: | MEDLINE 1.5.1.41 |
| RHEA:31455 | NAD(+) + reduced riboflavin = 2 H(+) + NADH + riboflavin |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]:[nH;+0:10]:[c;H0;+0:11]1:[c;H0;+0:12](:[*:13])-[NH;+0:14]-[*:15]:[*:16]-[N;H0;+0:17]-1-[*:18]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]:[n;H0;+0:10]:[c;H0;+0:11]1:[n;H0;+0:17](-[*:18]):[*:16]:[*:15]:[n;H0;+0:14]:[c;H0;+0:12]-1:[*:13] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| NAD(P)H:flavin oxidoreductase of Escherichia coli. A ferric iron reductase participating in the generation of the free radical of ribonucleotide reductase. | Fontecave M, Eliasson R, Reichard P | 1987 Sep 5 | 3305505 |
| Characterization of the flavin reductase gene (fre) of Escherichia coli and construction of a plasmid for overproduction of the enzyme. | Spyrou G, Haggård-Ljungquist E, Krook M, Jörnvall H, Nilsson E, Reichard P | 1991 Jun | 2050627 |
| Crystal structure of NAD(P)H:flavin oxidoreductase from Escherichia coli. | Ingelman M, Ramaswamy S, Nivière V, Fontecave M, Eklund H | 1999 Jun 1 | 10353815 |
| RHEA:19377 | NADP(+) + reduced riboflavin = 2 H(+) + NADPH + riboflavin |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]:[nH;+0:10]:[c;H0;+0:11]1:[c;H0;+0:12](:[*:13])-[NH;+0:14]-[*:15]:[*:16]-[N;H0;+0:17]-1-[*:18]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:9]:[n;H0;+0:10]:[c;H0;+0:11]1:[n;H0;+0:17](-[*:18]):[*:16]:[*:15]:[n;H0;+0:14]:[c;H0;+0:12]-1:[*:13] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of a second form of NADPH-flavin reductase purified from human erythrocytes. | Yubisui T, Tamura M, Takeshita M | 1987 Jul | 3453680 |
| NAD(P)H:flavin oxidoreductase of Escherichia coli. A ferric iron reductase participating in the generation of the free radical of ribonucleotide reductase. | Fontecave M, Eliasson R, Reichard P | 1987 Sep 5 | 3305505 |
| Characterization of the flavin reductase gene (fre) of Escherichia coli and construction of a plasmid for overproduction of the enzyme. | Spyrou G, Haggård-Ljungquist E, Krook M, Jörnvall H, Nilsson E, Reichard P | 1991 Jun | 2050627 |
| Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B). | Cunningham O, Gore MG, Mantle TJ | 2000 Jan 15 | 10620517 |
| Crystal structure of NAD(P)H:flavin oxidoreductase from Escherichia coli. | Ingelman M, Ramaswamy S, Nivière V, Fontecave M, Eklund H | 1999 Jun 1 | 10353815 |