EC number:1.5.1.43
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.5 Acting on the CH-NH group of donors |
| 1.5.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.5.1.43 |
|---|---|
| Description: | Carboxynorspermidine synthase. |
| Alternative Name: |
Carboxyspermidine dehydrogenase. Carboxynorspermidine dehydrogenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.5.1.43 |
| BRENDA Enzyme Link: | BRENDA 1.5.1.43 |
| KEGG Enzyme Link: | KEGG1.5.1.43 |
| BioCyc Enzyme Link: | BioCyc 1.5.1.43 |
| ExPASy Enzyme Link: | ExPASy1.5.1.43 |
| EC2PDB Enzyme Link: | EC2PDB 1.5.1.43 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.5.1.43 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.5.1.43 |
| IntEnz Enzyme Link: | IntEnz 1.5.1.43 |
| MEDLINE Enzyme Link: | MEDLINE 1.5.1.43 |
| RHEA:34115 | carboxynorspermidine + H2O + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[C;H0;+0:7](-[*:8])-[CH2;+0:9]-[CH;+0:10]=[CH;+0:11]-1.[*:12]-[NH2;+0:13].[H+;H0:14]>>[*:1]-[CH2;+0:2]-[NH;+0:13]-[*:12].[*:4]-[n+;H0:5]1:[cH;+0:6]:[c;H0;+0:7](-[*:8]):[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:1.[OH2;+0:3] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and some properties of carboxynorspermidine synthase participating in a novel biosynthetic pathway for norspermidine in Vibrio alginolyticus. | Nakao H, Shinoda S, Yamamoto S | 1991 Jul | 1955861 |
| An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae. | Lee J, Sperandio V, Frantz DE, Longgood J, Camilli A, Phillips MA, Michael AJ | 2009 Apr 10 | 19196710 |
| RHEA:34111 | carboxyspermidine + H2O + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[C;H0;+0:7](-[*:8])-[CH2;+0:9]-[CH;+0:10]=[CH;+0:11]-1.[*:12]-[NH2;+0:13].[H+;H0:14]>>[*:1]-[CH2;+0:2]-[NH;+0:13]-[*:12].[*:4]-[n+;H0:5]1:[cH;+0:6]:[c;H0;+0:7](-[*:8]):[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:1.[OH2;+0:3] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota. | Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ | 2011 Dec 16 | 22025614 |
| Purification and some properties of carboxynorspermidine synthase participating in a novel biosynthetic pathway for norspermidine in Vibrio alginolyticus. | Nakao H, Shinoda S, Yamamoto S | 1991 Jul | 1955861 |
| An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae. | Lee J, Sperandio V, Frantz DE, Longgood J, Camilli A, Phillips MA, Michael AJ | 2009 Apr 10 | 19196710 |