EC number:1.5.1.6
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.5 Acting on the CH-NH group of donors |
| 1.5.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.5.1.6 | ||
|---|---|---|---|
| Description: | Formyltetrahydrofolate dehydrogenase. | ||
| Alternative Name: |
10-formyltetrahydrofolate dehydrogenase. | ||
| Prosite: | PDOC00068; | ||
| PDB: |
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| Cath: | 1.10.1200.10; 3.40.605.10; 3.40.309.10; 3.40.50.170; 3.10.25.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.5.1.6 |
| BRENDA Enzyme Link: | BRENDA 1.5.1.6 |
| KEGG Enzyme Link: | KEGG1.5.1.6 |
| BioCyc Enzyme Link: | BioCyc 1.5.1.6 |
| ExPASy Enzyme Link: | ExPASy1.5.1.6 |
| EC2PDB Enzyme Link: | EC2PDB 1.5.1.6 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.5.1.6 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.5.1.6 |
| IntEnz Enzyme Link: | IntEnz 1.5.1.6 |
| MEDLINE Enzyme Link: | MEDLINE 1.5.1.6 |
| RHEA:10180 | (6S)-10-formyltetrahydrofolate + H2O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[*:9]=[CH;+0:10]-[N;H0;+0:11](-[*:12])-[*:13].[OH2;+0:14]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[*:12]-[NH;+0:11]-[*:13].[*:9]=[C;H0;+0:10]=[O;H0;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Partial purification of a 10-formyl-tetrahydrofolate: NADP oxidoreductase from mammalian liver. | Kutzbach C, Stokstad EL | 1968 Jan 25 | 4384443 |
| 10-formyltetrahydrofolate dehydrogenase requires a 4'-phosphopantetheine prosthetic group for catalysis. | Donato H, Krupenko NI, Tsybovsky Y, Krupenko SA | 2007 Nov 23 | 17884809 |
| Crystal structures of the carboxyl terminal domain of rat 10-formyltetrahydrofolate dehydrogenase: implications for the catalytic mechanism of aldehyde dehydrogenases. | Tsybovsky Y, Donato H, Krupenko NI, Davies C, Krupenko SA | 2007 Mar 20 | 17302434 |
| Structures of the hydrolase domain of human 10-formyltetrahydrofolate dehydrogenase and its complex with a substrate analogue. | Kursula P, Schüler H, Flodin S, Nilsson-Ehle P, Ogg DJ, Savitsky P, Nordlund P, Stenmark P | 2006 Nov | 17057331 |
| The crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase: mechanism of hydrolysis and its interplay with the dehydrogenase domain. | Chumanevich AA, Krupenko SA, Davies C | 2004 Apr 2 | 14729668 |