EC number:1.5.1.7
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.5 Acting on the CH-NH group of donors |
| 1.5.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.5.1.7 |
|---|---|
| Description: | Saccharopine dehydrogenase (NAD(+), L-lysine-forming). |
| Alternative Name: |
Lysine-2-oxoglutarate reductase. |
| Cath: | 3.30.360.10; 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.5.1.7 |
| BRENDA Enzyme Link: | BRENDA 1.5.1.7 |
| KEGG Enzyme Link: | KEGG1.5.1.7 |
| BioCyc Enzyme Link: | BioCyc 1.5.1.7 |
| ExPASy Enzyme Link: | ExPASy1.5.1.7 |
| EC2PDB Enzyme Link: | EC2PDB 1.5.1.7 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.5.1.7 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.5.1.7 |
| IntEnz Enzyme Link: | IntEnz 1.5.1.7 |
| MEDLINE Enzyme Link: | MEDLINE 1.5.1.7 |
| RHEA:12440 | H2O + L-saccharopine + NAD(+) = 2-oxoglutarate + H(+) + L-lysine + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[NH;+0:4]-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1.[OH2;+0:14]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:14].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1.[*:5]-[NH2;+0:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Active-site residues of saccharopine dehydrogenase (NAD+, lysine-forming) from baker's yeast. | Fujioka M | 1981 Aug | 7021257 |
| Chemical mechanism of saccharopine dehydrogenase (NAD+, L-lysine-forming) as deduced from initial rate pH studies. | Fujioka M | 1984 May 1 | 6712252 |
| A kinetic study of saccharopine dehydrogenase reaction. | Fujioka M, Nakatani Y | 1970 Sep | 4318475 |
| Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. IV. Saccharopine dehydrogenase. | Saunders PP, Broquist HP | 1966 Jul 25 | 4287986 |
| A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae. | Xu H, Alguindigue SS, West AH, Cook PF | 2007 Jan 23 | 17223709 |
| Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae. | Xu H, West AH, Cook PF | 2006 Oct 3 | 17002315 |