EC number:1.5.1.8
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.5 Acting on the CH-NH group of donors |
| 1.5.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.5.1.8 |
|---|---|
| Description: | Saccharopine dehydrogenase (NADP(+), L-lysine-forming). |
| Alternative Name: |
Lysine-ketoglutarate reductase. Lysine-2-oxoglutarate reductase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.5.1.8 |
| BRENDA Enzyme Link: | BRENDA 1.5.1.8 |
| KEGG Enzyme Link: | KEGG1.5.1.8 |
| BioCyc Enzyme Link: | BioCyc 1.5.1.8 |
| ExPASy Enzyme Link: | ExPASy1.5.1.8 |
| EC2PDB Enzyme Link: | EC2PDB 1.5.1.8 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.5.1.8 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.5.1.8 |
| IntEnz Enzyme Link: | IntEnz 1.5.1.8 |
| MEDLINE Enzyme Link: | MEDLINE 1.5.1.8 |
| RHEA:19373 | H2O + L-saccharopine + NADP(+) = 2-oxoglutarate + H(+) + L-lysine + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[NH;+0:4]-[*:5].[*:6]-[n+;H0:7]1:[cH;+0:8]:[cH;+0:9]:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:1.[OH2;+0:14]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:14].[*:6]-[N;H0;+0:7]1-[CH;+0:8]=[CH;+0:9]-[CH2;+0:10]-[C;H0;+0:11](-[*:12])=[CH;+0:13]-1.[*:5]-[NH2;+0:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities. | Markovitz PJ, Chuang DT, Cox RP | 1984 Oct 10 | 6434529 |