EC number:1.5.1.9
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.5 Acting on the CH-NH group of donors |
| 1.5.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.5.1.9 |
|---|---|
| Description: | Saccharopine dehydrogenase (NAD(+), L-glutamate-forming). |
| Alternative Name: |
Saccharopin dehydrogenase. Aminoadipic semialdehyde synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.5.1.9 |
| BRENDA Enzyme Link: | BRENDA 1.5.1.9 |
| KEGG Enzyme Link: | KEGG1.5.1.9 |
| BioCyc Enzyme Link: | BioCyc 1.5.1.9 |
| ExPASy Enzyme Link: | ExPASy1.5.1.9 |
| EC2PDB Enzyme Link: | EC2PDB 1.5.1.9 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.5.1.9 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.5.1.9 |
| IntEnz Enzyme Link: | IntEnz 1.5.1.9 |
| MEDLINE Enzyme Link: | MEDLINE 1.5.1.9 |
| RHEA:24520 | H2O + L-saccharopine + NAD(+) = (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[CH2;+0:3]-[*:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1.[OH2;+0:13]>>[*:4]-[CH;+0:3]=[O;H0;+0:13].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1.[*:1]-[NH2;+0:2] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities. | Markovitz PJ, Chuang DT, Cox RP | 1984 Oct 10 | 6434529 |