EC number:1.5.5.3
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.5 Acting on the CH-NH group of donors |
| 1.5.5 With a quinone or similar compound as acceptor |
| ID: | 1.5.5.3 |
|---|---|
| Description: | Hydroxyproline dehydrogenase. |
| Alternative Name: |
HYPDH. Hydroxyproline oxidase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.5.5.3 |
| BRENDA Enzyme Link: | BRENDA 1.5.5.3 |
| KEGG Enzyme Link: | KEGG1.5.5.3 |
| BioCyc Enzyme Link: | BioCyc 1.5.5.3 |
| ExPASy Enzyme Link: | ExPASy1.5.5.3 |
| EC2PDB Enzyme Link: | EC2PDB 1.5.5.3 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.5.5.3 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.5.5.3 |
| IntEnz Enzyme Link: | IntEnz 1.5.5.3 |
| MEDLINE Enzyme Link: | MEDLINE 1.5.5.3 |
| RHEA:52512 | a quinone + trans-4-hydroxy-L-proline = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[C;H0;+0:3](-[*:4])-[C;H0;+0:5](=[O;H0;+0:6])-[C;H0;+0:7](-[*:8])=[C;H0;+0:9](-[*:10])-[C;H0;+0:11]-1=[O;H0;+0:12].[*:13]-[NH;+0:14]-[CH2;+0:15]-[*:16]>>[*:13]-[N;H0;+0:14]=[CH;+0:15]-[*:16].[*:1]-[c;H0;+0:2]1:[c;H0;+0:11](-[OH;+0:12]):[c;H0;+0:9](-[*:10]):[c;H0;+0:7](-[*:8]):[c;H0;+0:5](-[OH;+0:6]):[c;H0;+0:3]:1-[*:4] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria. | Summitt CB, Johnson LC, Jönsson TJ, Parsonage D, Holmes RP, Lowther WT | 2015 Mar 1 | 25697095 |
| A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species. | Cooper SK, Pandhare J, Donald SP, Phang JM | 2008 Apr 18 | 18287100 |