EC number:1.6.2.2
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.6 Acting on NADH or NADPH |
| 1.6.2 With a heme protein as acceptor |
| ID: | 1.6.2.2 |
|---|---|
| Description: | Cytochrome-b5 reductase. |
| Cath: | 3.40.50.80; 2.40.30.10; 3.10.120.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.6.2.2 |
| BRENDA Enzyme Link: | BRENDA 1.6.2.2 |
| KEGG Enzyme Link: | KEGG1.6.2.2 |
| BioCyc Enzyme Link: | BioCyc 1.6.2.2 |
| ExPASy Enzyme Link: | ExPASy1.6.2.2 |
| EC2PDB Enzyme Link: | EC2PDB 1.6.2.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.6.2.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.6.2.2 |
| IntEnz Enzyme Link: | IntEnz 1.6.2.2 |
| MEDLINE Enzyme Link: | MEDLINE 1.6.2.2 |
| RHEA:46680 | 2 [Fe(III)-cytochrome b5] + NADH = 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[Fe+3;H0:9].[Fe+3;H0:10]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[Fe+2;H0:9].[Fe+2;H0:10] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and properties of soluble NADH-cytochrome b5 reductase of rabbit erythrocytes. | Yubisui T, Takeshita M | 1982 May | 7096301 |
| One-electron oxidation-reduction properties of hepatic NADH-cytochrome b5 reductase. | Iyanagi T, Watanabe S, Anan KF | 1984 Mar 27 | 6326802 |
| Human cytochrome b5 reductase: structure, function, and potential applications. | Elahian F, Sepehrizadeh Z, Moghimi B, Mirzaei SA | 2014 Jun | 23113554 |
| Role of cysteine residues in human NADH-cytochrome b5 reductase studied by site-directed mutagenesis. Cys-273 and Cys-283 are located close to the NADH-binding site but are not catalytically essential. | Shirabe K, Yubisui T, Nishino T, Takeshita M | 1991 Apr 25 | 2019583 |
| Cytochrome b5 reductase: role of the si-face residues, proline 92 and tyrosine 93, in structure and catalysis. | Marohnic CC, Crowley LJ, Davis CA, Smith ET, Barber MJ | 2005 Feb 22 | 15709757 |
| Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells. | Zhu H, Qiu H, Yoon HW, Huang S, Bunn HF | 1999 Dec 21 | 10611283 |