EC number:1.6.3.1

Enzyme

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     1. Oxidoreductases
        1.6 Acting on NADH or NADPH
            1.6.3 With oxygen as acceptor
ID:1.6.3.1
Description:NAD(P)H oxidase (H(2)O(2)-forming).
Alternative Name: Thyroid oxidase 2.
Thyroid oxidase.
Thyroid NADPH oxidase.
THOX2.
ThOX.
NAD(P)H oxidase.
Dual oxidase.
Prosite: PDOC00394;
PDB:
PDBScop
1ATJ 8032094; 8044472; 8032094; 8044472; 8032094; 8044472; 8032094; 8044472; 8032094; 8044472; 8032094; 8044472;
4ATJ 8032094; 8044472; 8032094; 8044472;
3ATJ 8032094; 8044472; 8032094; 8044472;
2ATJ 8032094; 8044472; 8032094; 8044472;
1GX2 8032094; 8044472; 8032094; 8044472;
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3D structure

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PDB

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1ATJ; 4ATJ; 3ATJ; 2ATJ; 1GX2; 7ATJ; 6ATJ; 2YLJ; 1W4Y; 1W4W; 1KZM; 1HCH; 1H5M; 1H5L; 1H5K; 1H5J; 1H5I; 1H5H; 1H5G; 1H5F; 1H5E; 1H5D; 1H5C; 1H5A; 1H58; 1H57; 1H55; 1GWU; 1GWT; 1GWO; 1GW2; 4EJX; 4PAE; 3X16; 3WXO; 3WNU; 1UB2; 1LYK; 1LYC; 1LY9; 1LY8; 1H3J; 2E3B; 2E3A; 2E39; 1HSR; 1GZB; 1GZA; 1CK6; 1C8I; 1ARY; 1ARX; 1ARW; 1ARV; 1ARU; 1ARP; 3VLM; 3VLL; 3VLK; 3VLJ; 3VLI; 3VLH; 3UW8; 1ITK; 5WBE; 5U6X; 4O1Z; 3N8Z; 3N8Y; 3N8X; 3N8W; 3N8V; 3KK6; 2AYL; 1Q4G; 1PTH; 1PRH; 1PGG; 1PGF; 1PGE; 1HT8; 1HT5; 1EQH; 1EQG; 1CQE; 2OYU; 2OYE; 1U67; 1IGZ; 1IGX; 1FE2; 1EBV; 1DIY; 2CCD; 2CCA; 1SJ2; 6BL4; 6BL3; 5COX; 4Z0L; 4RUT; 4RRZ; 4RRY; 4RRW; 4OTJ; 4M11; 4M10; 4FM5; 4COX; 3RR3; 3PGH; 3NTG; 3NTB; 3MQE; 3LN1; 3LN0; 1PXX; 1DDX; 1CX2; 6COX; 5JW1; 5JVZ; 5JVY; 5FDQ; 4RRX; 4PH9; 4OTY; 4E1G; 3TZI; 3QMO; 3QH0; 3Q7D; 3OLU; 3OLT; 3NT1; 3MDL; 3KRK; 3HS7; 3HS6; 3HS5; 1CVU; 5W58; 4RS0; 1QO4; 1PA2; 1QGJ; 1SCH; 1APX; 1LGA; 1LLP; 1U75; 5CIH; 5CIE; 5CIC; 2PCC; 2B11; 1S6V; 2JTI; 3E2N; 2PCB; 4NFG; 2N18; 5CIG; 5CIF; 5CID; 5CIB; 2B10; 1U74; 2GB8; 2B12; 2B0Z; 2BCN; 4XVA; 4JB4; 7CCP; 6CCP; 5EJX; 5EJT; 5D6M; 5CCP; 4XV8; 4XV7; 4XV6; 4XV5; 4XV4; 4CVJ; 4CVI; 4CCX; 4CCP; 4A7M; 4A78; 4A71; 4A6Z; 3R99; 3R98; 3M2I; 3M2H; 3M2G; 3M2F; 3M2E; 3M2D; 3M2C; 3M2B; 3M2A; 3M29; 3M28; 3M27; 3M26; 3M25; 3M23; 3EXB; 3E2O; 3CCX; 3CCP; 2YCG; 2Y5A; 2XJ8; 2XJ5; 2XIL; 2X08; 2X07; 2V2E; 2V23; 2RC2; 2RC1; 2RC0; 2RBZ; 2RBY; 2RBX; 2RBW; 2RBV; 2RBU; 2RBT; 2ICV; 2IA8; 2EUU; 2EUT; 2EUS; 2EUR; 2EUQ; 2EUP; 2EUO; 2EUN; 2CYP; 2CEP; 2CCP; 2AS6; 2AS4; 2AS3; 2AS2; 2AS1; 2AQD; 2ANZ; 1ZBZ; 1ZBY; 1Z53; 1STQ; 1SOG; 1SDQ; 1SBM; 1S73; 1RYC; 1ML2; 1MKR; 1MKQ; 1MK8; 1KXN; 1KXM; 1KRJ; 1KOK; 1JDR; 1JCI; 1EBE; 1DSP; 1DSO; 1DSG; 1DSE; 1DS4; 1DJ5; 1DJ1; 1DCC; 1CYF; 1CPG; 1CPF; 1CPE; 1CPD; 1CMU; 1CMT; 1CMQ; 1CMP; 1CCP; 1CCL; 1CCK; 1CCJ; 1CCI; 1CCG; 1CCE; 1CCC; 1CCB; 1CCA; 1BVA; 1BJ9; 1BES; 1BEQ; 1BEP; 1BEM; 1BEK; 1BEJ; 1AEV; 1AEU; 1AET; 1AES; 1AEQ; 1AEO; 1AEN; 1AEM; 1AEK; 1AEJ; 1AEH; 1AEG; 1AEF; 1AED; 1AEB; 1AC8; 1AC4; 1AA4; 1A2G; 1A2F; 3M8M; 3M5Q; 1YZR; 1YZP; 1YYG; 1YYD; 1MNP; 1MN2; 1MN1; 6CEK; 6CDQ; 6CC6; 6CAW; 6B9B; 5V53; 5V4O; 5TXQ; 5SYY; 5SYX; 5SYW; 5SYV; 5SYU; 5SYL; 5SYK; 5SYJ; 5SYI; 5SYH; 5SXX; 5SXW; 5SXT; 5SXS; 5SXR; 5SXQ; 5SX7; 5SX6; 5SX3; 5SX2; 5SX1; 5SX0; 5SW6; 5SW5; 5SW4; 5L05; 5KT9; 5KT8; 5KSN; 5KSK; 5KSG; 5KSF; 5KQQ; 5KQN; 5KQK; 5KQI; 5KQH; 5KQ6; 5KQ3; 5KQ2; 5KQ0; 6MQ1; 6MQ0; 6MPY; 6ERC; 6CFQ; 6BMT; 6AZP; 6A6Q; 6A4Y; 5ZWW; 5ZGS; 5WV3; 5WHS; 5WHQ; 5UZU; 5MFA; 5L02; 5KIR; 5JHZ; 5JHY; 5JHX; 5IKV; 5IKT; 5IKR; 5IKQ; 5GLS; 5GH0; 5FNE; 5FNB; 5FIW; 5F1A; 5F19; 5CJH; 5B72; 5AOG; 5ABQ; 5ABO; 5ABN; 4Y55; 4PNX; 4P4Q; 4NT3; 4NJB; 4KSZ; 4HHS; 4HHR; 4GN6; 4GM7; 4G05; 4FEF; 4FDQ; 4FCS; 4FCN; 4DL1; 4C51; 4C50; 4C1M; 4BM0; 4BLZ; 4BLY; 4BLX; 4BLN; 4BLL; 4BLK; 3ZS1; 3ZS0; 3V6Q; 3UT2; 3UBA; 3TGY; 3S4F; 3R5O; 3R4X; 3QL6; 3Q9K; 3PY4; 3OGW; 3NYH; 3KRQ; 3I6N; 3GCL; 3GCK; 3GCJ; 3GC1; 3FNL; 3FMU; 3FM6; 3FM4; 3FM1; 3FKG; 3FJW; 3FAQ; 3F9P; 3ERI; 3ERH; 3BXI; 2Z5Z; 2W23; 2VKA; 2QRB; 2QQT; 2QPK; 2PUM; 2PT3; 2O86; 2NQX; 2IPS; 2GJM; 2BOQ; 1QPA; 1MYP; 1MHL; 1DNW; 1DNU; 1D7W; 1D5L; 1D2V; 1CXP; 1B85; 1B82; 1B80; 1AEE;

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.6.3.1
BRENDA Enzyme Link: BRENDA 1.6.3.1
KEGG Enzyme Link: KEGG1.6.3.1
BioCyc Enzyme Link: BioCyc 1.6.3.1
ExPASy Enzyme Link: ExPASy1.6.3.1
EC2PDB Enzyme Link: EC2PDB 1.6.3.1
ExplorEnz Enzyme Link: ExplorEnz 1.6.3.1
PRIAM enzyme-specific profiles Link: PRIAM 1.6.3.1
IntEnz Enzyme Link: IntEnz 1.6.3.1
MEDLINE Enzyme Link: MEDLINE 1.6.3.1

EC number:1.6.3.1

MSA:

1.6.3.1;
Phylogenetic Tree:

1.6.3.1;
Uniprot:
M-CSA:
RHEA:11264 H(+) + NADH + O2 = H2O2 + NAD(+)
RULE(radius=1) [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[H+;H0:9].[O;H0;+0:10]=[O;H0;+0:11]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[OH;+0:10]-[OH;+0:11]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane.Dupuy C, Virion A, Ohayon R, Kaniewski J, Dème D, Pommier J1991 Feb 251995628
Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism.Moreno JC, Bikker H, Kempers MJ, van Trotsenburg AS, Baas F, de Vijlder JJ, Vulsma T, Ris-Stalpers C2002 Jul 1112110737
Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.De Deken X, Wang D, Dumont JE, Miot F2002 Feb 1511822874
Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.De Deken X, Wang D, Many MC, Costagliola S, Libert F, Vassart G, Dumont JE, Miot F2000 Jul 2810806195
Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas.Dupuy C, Ohayon R, Valent A, Noël-Hudson MS, Dème D, Virion A1999 Dec 2410601291
Biochemical characterization of a Ca2+/NAD(P)H-dependent H2O2 generator in human thyroid tissue.Leseney AM, Dème D, Legué O, Ohayon R, Chanson P, Sales JP, Carvalho DP, Dupuy C, Virion A1999 Apr10401672
RHEA:11260 H(+) + NADPH + O2 = H2O2 + NADP(+)
RULE(radius=1) [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[H+;H0:9].[O;H0;+0:10]=[O;H0;+0:11]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[OH;+0:10]-[OH;+0:11]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane.Dupuy C, Virion A, Ohayon R, Kaniewski J, Dème D, Pommier J1991 Feb 251995628
Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism.Moreno JC, Bikker H, Kempers MJ, van Trotsenburg AS, Baas F, de Vijlder JJ, Vulsma T, Ris-Stalpers C2002 Jul 1112110737
Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.De Deken X, Wang D, Dumont JE, Miot F2002 Feb 1511822874
Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.De Deken X, Wang D, Many MC, Costagliola S, Libert F, Vassart G, Dumont JE, Miot F2000 Jul 2810806195
Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas.Dupuy C, Ohayon R, Valent A, Noël-Hudson MS, Dème D, Virion A1999 Dec 2410601291
Biochemical characterization of a Ca2+/NAD(P)H-dependent H2O2 generator in human thyroid tissue.Leseney AM, Dème D, Legué O, Ohayon R, Chanson P, Sales JP, Carvalho DP, Dupuy C, Virion A1999 Apr10401672