EC number:1.6.3.3
| ID: | 1.6.3.3 |
|---|---|
| Description: | NADH oxidase (H(2)O(2)-forming). |
| Alternative Name: |
H(2)O(2)-forming NADH oxidase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.6.3.3 |
| BRENDA Enzyme Link: | BRENDA 1.6.3.3 |
| KEGG Enzyme Link: | KEGG1.6.3.3 |
| BioCyc Enzyme Link: | BioCyc 1.6.3.3 |
| ExPASy Enzyme Link: | ExPASy1.6.3.3 |
| EC2PDB Enzyme Link: | EC2PDB 1.6.3.3 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.6.3.3 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.6.3.3 |
| IntEnz Enzyme Link: | IntEnz 1.6.3.3 |
| MEDLINE Enzyme Link: | MEDLINE 1.6.3.3 |
| RHEA:11264 | H(+) + NADH + O2 = H2O2 + NAD(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[H+;H0:9].[O;H0;+0:10]=[O;H0;+0:11]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[OH;+0:10]-[OH;+0:11] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane. | Dupuy C, Virion A, Ohayon R, Kaniewski J, Dème D, Pommier J | 1991 Feb 25 | 1995628 |
| Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism. | Moreno JC, Bikker H, Kempers MJ, van Trotsenburg AS, Baas F, de Vijlder JJ, Vulsma T, Ris-Stalpers C | 2002 Jul 11 | 12110737 |
| Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system. | De Deken X, Wang D, Dumont JE, Miot F | 2002 Feb 15 | 11822874 |
| Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. | De Deken X, Wang D, Many MC, Costagliola S, Libert F, Vassart G, Dumont JE, Miot F | 2000 Jul 28 | 10806195 |
| Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas. | Dupuy C, Ohayon R, Valent A, Noël-Hudson MS, Dème D, Virion A | 1999 Dec 24 | 10601291 |
| Biochemical characterization of a Ca2+/NAD(P)H-dependent H2O2 generator in human thyroid tissue. | Leseney AM, Dème D, Legué O, Ohayon R, Chanson P, Sales JP, Carvalho DP, Dupuy C, Virion A | 1999 Apr | 10401672 |