Enzyme

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EC Tree
     1. Oxidoreductases
        1.6 Acting on NADH or NADPH
            1.6.3 With oxygen as acceptor
ID:1.6.3.4
Description:NADH oxidase (H(2)O-forming).
Alternative Name: H(2)O-forming NADH oxidase.

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 1.6.3.4
BRENDA Enzyme Link: BRENDA 1.6.3.4
KEGG Enzyme Link: KEGG1.6.3.4
BioCyc Enzyme Link: BioCyc 1.6.3.4
ExPASy Enzyme Link: ExPASy1.6.3.4
EC2PDB Enzyme Link: EC2PDB 1.6.3.4
ExplorEnz Enzyme Link: ExplorEnz 1.6.3.4
PRIAM enzyme-specific profiles Link: PRIAM 1.6.3.4
IntEnz Enzyme Link: IntEnz 1.6.3.4
MEDLINE Enzyme Link: MEDLINE 1.6.3.4
MSA:

1.6.3.4;

Phylogenetic Tree:

1.6.3.4;

Uniprot:
M-CSA:
RHEA:37799 2 H(+) + 2 NADH + O2 = 2 H2O + 2 NAD(+)
RULE(radius=1) [*:1]-[C;H0;+0:2]1=[CH;+0:3]-[N;H0;+0:4](-[*:5])-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-1.[*:9]-[N;H0;+0:10]1-[CH;+0:11]=[C;H0;+0:12](-[*:13])-[CH2;+0:14]-[CH;+0:15]=[CH;+0:16]-1.[H+;H0:17].[H+;H0:18].[O;H0;+0:19]=[O;H0;+0:20]>>[*:1]-[c;H0;+0:2]1:[cH;+0:3]:[n+;H0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]-[n+;H0:10]1:[cH;+0:11]:[c;H0;+0:12](-[*:13]):[cH;+0:14]:[cH;+0:15]:[cH;+0:16]:1.[OH2;+0:19].[OH2;+0:20]
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References

TitleAuthorsDatePubMed ID
O2 and reactive oxygen species detoxification complex, composed of O2-responsive NADH:rubredoxin oxidoreductase-flavoprotein A2-desulfoferrodoxin operon enzymes, rubperoxin, and rubredoxin, in Clostridium acetobutylicum.Kawasaki S, Sakai Y, Takahashi T, Suzuki I, Niimura Y2009 Feb19124587
Molecular cloning and sequence analysis of the gene encoding the H2O-forming NADH oxidase from Streptococcus mutans.Matsumoto J, Higuchi M, Shimada M, Yamamoto Y, Kamio Y1996 Jan8824824
Identification of two distinct NADH oxidases corresponding to H2O2-forming oxidase and H2O-forming oxidase induced in Streptococcus mutans.Higuchi M, Shimada M, Yamamoto Y, Hayashi T, Koga T, Kamio Y1993 Oct8254304
Isolation and properties of an H2O-forming NADH oxidase from Streptococcus faecalis.Schmidt HL, Stöcklein W, Danzer J, Kirch P, Limbach B1986 Apr 13082630
Cloning and characterization of a thermostable H2O-forming NADH oxidase from Lactobacillus rhamnosus.Zhang YW, Tiwari MK, Gao H, Dhiman SS, Jeya M, Lee JK2012 Apr 522418266
An archaeal NADH oxidase causes damage to both proteins and nucleic acids under oxidative stress.Jia B, Lee S, Pham BP, Cho YS, Yang JK, Byeon HS, Kim JC, Cheong GW2010 Apr20213313
Reductive dioxygen scavenging by flavo-diiron proteins of Clostridium acetobutylicum.Hillmann F, Riebe O, Fischer RJ, Mot A, Caranto JD, Kurtz DM Jr, Bahl H2009 Jan 519084524
Hexameric ring structure of a thermophilic archaeon NADH oxidase that produces predominantly H2O.Jia B, Park SC, Lee S, Pham BP, Yu R, Le TL, Han SW, Yang JK, Choi MS, Baumeister W, Cheong GW2008 Nov18959761
Purification and characterization of an H2O-forming NADH oxidase from Clostridium aminovalericum: existence of an oxygen-detoxifying enzyme in an obligate anaerobic bacteria.Kawasaki S, Ishikura J, Chiba D, Nishino T, Niimura Y2004 Apr15014929