EC number:1.6.5.5
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.6 Acting on NADH or NADPH |
| 1.6.5 With a quinone or similar compound as acceptor |
| ID: | 1.6.5.5 | ||
|---|---|---|---|
| Description: | NADPH:quinone reductase. | ||
| Alternative Name: |
Zeta-crystallin. Quinone oxidoreductase. | ||
| Prosite: | PDOC00058; | ||
| PDB: |
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| Cath: | 3.40.50.720; 3.90.180.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.6.5.5 |
| BRENDA Enzyme Link: | BRENDA 1.6.5.5 |
| KEGG Enzyme Link: | KEGG1.6.5.5 |
| BioCyc Enzyme Link: | BioCyc 1.6.5.5 |
| ExPASy Enzyme Link: | ExPASy1.6.5.5 |
| EC2PDB Enzyme Link: | EC2PDB 1.6.5.5 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.6.5.5 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.6.5.5 |
| IntEnz Enzyme Link: | IntEnz 1.6.5.5 |
| MEDLINE Enzyme Link: | MEDLINE 1.6.5.5 |
| RHEA:14269 | 2 a quinone + H(+) + NADPH = 2 a 1,4-benzosemiquinone + NADP(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[H+;H0:9].[O;H0;+0:10]=[C;H0;+0:11]1-[CH;+0:12]=[CH;+0:13]-[C;H0;+0:14](=[O;H0;+0:15])-[CH;+0:16]=[CH;+0:17]-1.[O;H0;+0:18]=[C;H0;+0:19]1-[CH;+0:20]=[CH;+0:21]-[C;H0;+0:22](=[O;H0;+0:23])-[CH;+0:24]=[CH;+0:25]-1>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[OH;+0:10]-[c;H0;+0:11]1:[cH;+0:12]:[cH;+0:13]:[c;H0;+0:14](-[OH;+0:15]):[cH;+0:16]:[cH;+0:17]:1.[OH;+0:18]-[c;H0;+0:19]1:[cH;+0:20]:[cH;+0:21]:[c;H0;+0:22](-[OH;+0:23]):[cH;+0:24]:[cH;+0:25]:1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Kinetic properties of camel lens zeta-crystallin. | Duhaiman AS | 1996 Oct | 8930141 |
| Identification and characterization of the enzymatic activity of zeta-crystallin from guinea pig lens. A novel NADPH:quinone oxidoreductase. | Rao PV, Krishna CM, Zigler JS Jr | 1992 Jan 5 | 1370456 |
| Interaction of camel lens zeta-crystallin with quinones: portrait of a substrate by fluorescence spectroscopy. | Bazzi MD | 2001 Nov 15 | 11697855 |
| Identification of zeta-crystallin/NADPH:quinone reductase as a renal glutaminase mRNA pH response element-binding protein. | Tang A, Curthoys NP | 2001 Jun 15 | 11294877 |