EC number:1.6.5.9
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.6 Acting on NADH or NADPH |
| 1.6.5 With a quinone or similar compound as acceptor |
| ID: | 1.6.5.9 |
|---|---|
| Description: | NADH:ubiquinone reductase (non-electrogenic). |
| Alternative Name: |
Ubiquinone reductase. NADH-ubiquinone reductase. NADH-ubiquinone oxidoreductase. NADH-Q6 oxidoreductase. NADH-CoQ reductase. NADH-CoQ oxidoreductase. NADH-coenzyme Q reductase. NADH-coenzyme Q oxidoreductase. NADH(2) dehydrogenase (ubiquinone). Electron transfer complex I. Coenzyme Q reductase. |
| Cath: | 3.50.50.100; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.6.5.9 |
| BRENDA Enzyme Link: | BRENDA 1.6.5.9 |
| KEGG Enzyme Link: | KEGG1.6.5.9 |
| BioCyc Enzyme Link: | BioCyc 1.6.5.9 |
| ExPASy Enzyme Link: | ExPASy1.6.5.9 |
| EC2PDB Enzyme Link: | EC2PDB 1.6.5.9 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.6.5.9 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.6.5.9 |
| IntEnz Enzyme Link: | IntEnz 1.6.5.9 |
| MEDLINE Enzyme Link: | MEDLINE 1.6.5.9 |
| RHEA:23152 | a ubiquinone + H(+) + NADH = a ubiquinol + NAD(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[C;H0;+0:3](-[*:4])-[C;H0;+0:5](=[O;H0;+0:6])-[C;H0;+0:7](-[*:8])=[C;H0;+0:9](-[*:10])-[C;H0;+0:11]-1=[O;H0;+0:12].[*:13]-[N;H0;+0:14]1-[CH;+0:15]=[C;H0;+0:16](-[*:17])-[CH2;+0:18]-[CH;+0:19]=[CH;+0:20]-1.[H+;H0:21]>>[*:1]-[c;H0;+0:2]1:[c;H0;+0:11](-[OH;+0:12]):[c;H0;+0:9](-[*:10]):[c;H0;+0:7](-[*:8]):[c;H0;+0:5](-[OH;+0:6]):[c;H0;+0:3]:1-[*:4].[*:13]-[n+;H0:14]1:[cH;+0:15]:[c;H0;+0:16](-[*:17]):[cH;+0:18]:[cH;+0:19]:[cH;+0:20]:1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of a rotenone-insensitive NADH:Q6 oxidoreductase from mitochondria of Saccharomyces cerevisiae. | de Vries S, Grivell LA | 1988 Sep 15 | 3138118 |
| Alternative NAD(P)H dehydrogenases of plant mitochondria. | Rasmusson AG, Soole KL, Elthon TE | 2004 | 15725055 |
| A single external enzyme confers alternative NADH:ubiquinone oxidoreductase activity in Yarrowia lipolytica. | Kerscher SJ, Okun JG, Brandt U | 1999 Jul | 10381390 |