EC number:1.7.1.12
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.7 Acting on other nitrogenous compounds as donors |
| 1.7.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.7.1.12 |
|---|---|
| Description: | N-hydroxy-2-acetamidofluorene reductase. |
| Alternative Name: |
N-hydroxy-2-acetylaminofluorene reductase. |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.7.1.12 |
| BRENDA Enzyme Link: | BRENDA 1.7.1.12 |
| KEGG Enzyme Link: | KEGG1.7.1.12 |
| BioCyc Enzyme Link: | BioCyc 1.7.1.12 |
| ExPASy Enzyme Link: | ExPASy1.7.1.12 |
| EC2PDB Enzyme Link: | EC2PDB 1.7.1.12 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.7.1.12 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.7.1.12 |
| IntEnz Enzyme Link: | IntEnz 1.7.1.12 |
| MEDLINE Enzyme Link: | MEDLINE 1.7.1.12 |
| RHEA:13113 | 2-acetamidofluorene + H2O + NADP(+) = H(+) + N-hydroxy-2-acetamidofluorene + NADPH |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[*:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1.[OH2;+0:12]>>[*:1]-[N;H0;+0:2](-[*:3])-[OH;+0:12].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The conversion of the carcinogen N-hydroxy-2-fluorenylacetamide to o-amidophenols by rat liver in vitro. An inducible enzymatic reaction. | Gutmann HR, Erickson RR | 1969 Apr 10 | 5780838 |
| Purification of N-hydroxy-2-acetylaminofluorene reductase from rabbit liver cytosol. | Kitamura S, Tatsumi K | 1985 Nov 27 | 4074379 |
| RHEA:13109 | 2-acetamidofluorene + H2O + NAD(+) = H(+) + N-hydroxy-2-acetamidofluorene + NADH |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[*:3].[*:4]-[n+;H0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9](-[*:10]):[cH;+0:11]:1.[OH2;+0:12]>>[*:1]-[N;H0;+0:2](-[*:3])-[OH;+0:12].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-[C;H0;+0:9](-[*:10])=[CH;+0:11]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The conversion of the carcinogen N-hydroxy-2-fluorenylacetamide to o-amidophenols by rat liver in vitro. An inducible enzymatic reaction. | Gutmann HR, Erickson RR | 1969 Apr 10 | 5780838 |
| Purification of N-hydroxy-2-acetylaminofluorene reductase from rabbit liver cytosol. | Kitamura S, Tatsumi K | 1985 Nov 27 | 4074379 |