EC number:1.7.1.9
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.7 Acting on other nitrogenous compounds as donors |
| 1.7.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.7.1.9 |
|---|---|
| Description: | Nitroquinoline-N-oxide reductase. |
| Alternative Name: |
NAD(P)H:4-nitroquinoline-N-oxide oxidoreductase. 4NQO reductase. 4-nitroquinoline 1-oxide reductase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.7.1.9 |
| BRENDA Enzyme Link: | BRENDA 1.7.1.9 |
| KEGG Enzyme Link: | KEGG1.7.1.9 |
| BioCyc Enzyme Link: | BioCyc 1.7.1.9 |
| ExPASy Enzyme Link: | ExPASy1.7.1.9 |
| EC2PDB Enzyme Link: | EC2PDB 1.7.1.9 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.7.1.9 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.7.1.9 |
| IntEnz Enzyme Link: | IntEnz 1.7.1.9 |
| MEDLINE Enzyme Link: | MEDLINE 1.7.1.9 |
| RHEA:22480 | 4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) = 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[*:3].[*:4]-[c;H0;+0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[n+;H0:9](-[*:10]):[cH;+0:11]:1.[*:12]-[n+;H0:13]1:[cH;+0:14]:[cH;+0:15]:[cH;+0:16]:[c;H0;+0:17](-[*:18]):[cH;+0:19]:1.[OH2;+0:20]>>[*:4]-[C;H0;+0:5]1=[CH;+0:11]-[N;H0;+0:9](-[*:10])-[CH;+0:8]=[CH;+0:7]-[CH2;+0:6]-1.[*:1]-[N+;H0:2](-[*:3])=[O;H0;+0:20].[*:12]-[N;H0;+0:13]1-[CH;+0:14]=[CH;+0:15]-[CH2;+0:16]-[C;H0;+0:17](-[*:18])=[CH;+0:19]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Nitroreductases and glutathione transferases that act on 4-nitroquinoline 1-oxide and their differential induction by butylated hydroxyanisole in mice. | Stanley JS, York JL, Benson AM | 1992 Jan 1 | 1370076 |
| RHEA:22476 | 4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) = 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[*:3].[*:4]-[c;H0;+0:5]1:[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:[n+;H0:9](-[*:10]):[cH;+0:11]:1.[*:12]-[n+;H0:13]1:[cH;+0:14]:[cH;+0:15]:[cH;+0:16]:[c;H0;+0:17](-[*:18]):[cH;+0:19]:1.[OH2;+0:20]>>[*:4]-[C;H0;+0:5]1=[CH;+0:11]-[N;H0;+0:9](-[*:10])-[CH;+0:8]=[CH;+0:7]-[CH2;+0:6]-1.[*:1]-[N+;H0:2](-[*:3])=[O;H0;+0:20].[*:12]-[N;H0;+0:13]1-[CH;+0:14]=[CH;+0:15]-[CH2;+0:16]-[C;H0;+0:17](-[*:18])=[CH;+0:19]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Nitroreductases and glutathione transferases that act on 4-nitroquinoline 1-oxide and their differential induction by butylated hydroxyanisole in mice. | Stanley JS, York JL, Benson AM | 1992 Jan 1 | 1370076 |