EC number:1.8.1.13

Enzyme

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     1. Oxidoreductases
        1.8 Acting on a sulfur group of donors
            1.8.1 With NAD+ or NADP+ as acceptor
ID:1.8.1.13
Description:Bis-gamma-glutamylcystine reductase.
Alternative Name: NADPH:bis-gamma-glutamylcysteine oxidoreductase.
Bis-gamma-glutamylcystine reductase (NADPH).
Cath: 3.30.390.30; 3.50.50.60;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.8.1.13
BRENDA Enzyme Link: BRENDA 1.8.1.13
KEGG Enzyme Link: KEGG1.8.1.13
BioCyc Enzyme Link: BioCyc 1.8.1.13
ExPASy Enzyme Link: ExPASy1.8.1.13
EC2PDB Enzyme Link: EC2PDB 1.8.1.13
ExplorEnz Enzyme Link: ExplorEnz 1.8.1.13
PRIAM enzyme-specific profiles Link: PRIAM 1.8.1.13
IntEnz Enzyme Link: IntEnz 1.8.1.13
MEDLINE Enzyme Link: MEDLINE 1.8.1.13

EC number:1.8.1.13

MSA:

1.8.1.13;
Phylogenetic Tree:

1.8.1.13;
Uniprot:
M-CSA:
RHEA:11980 2 L-gamma-glutamyl-L-cysteine + NADP(+) = bis-gamma-glutamylcystine + H(+) + NADPH
RULE(radius=1) [*:1]-[SH;+0:2].[*:3]-[SH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1.[*:1]-[S;H0;+0:2]-[S;H0;+0:4]-[*:3]
Reaction
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References

TitleAuthorsDatePubMed ID
The novel disulfide reductase bis-gamma-glutamylcystine reductase and dihydrolipoamide dehydrogenase from Halobacterium halobium: purification by immobilized-metal-ion affinity chromatography and properties of the enzymes.Sundquist AR, Fahey RC1988 Aug3136140
The function of gamma-glutamylcysteine and bis-gamma-glutamylcystine reductase in Halobacterium halobium.Sundquist AR, Fahey RC1989 Jan 152910862
The orphan protein bis-γ-glutamylcystine reductase joins the pyridine nucleotide disulfide reductase family.Kim J, Copley SD2013 Apr 3023560638