EC number:1.8.1.14
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.8 Acting on a sulfur group of donors |
| 1.8.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.8.1.14 |
|---|---|
| Description: | CoA-disulfide reductase. |
| Alternative Name: |
NADH:CoA-disulfide oxidoreductase. Coenzyme A disulfide reductase. CoADR. CoA-disulfide reductase (NAD(P)H). |
| Cath: | 3.30.390.30; 3.50.50.60; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.8.1.14 |
| BRENDA Enzyme Link: | BRENDA 1.8.1.14 |
| KEGG Enzyme Link: | KEGG1.8.1.14 |
| BioCyc Enzyme Link: | BioCyc 1.8.1.14 |
| ExPASy Enzyme Link: | ExPASy1.8.1.14 |
| EC2PDB Enzyme Link: | EC2PDB 1.8.1.14 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.8.1.14 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.8.1.14 |
| IntEnz Enzyme Link: | IntEnz 1.8.1.14 |
| MEDLINE Enzyme Link: | MEDLINE 1.8.1.14 |
| RHEA:14705 | 2 CoA + NADP(+) = CoA-disulfide + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[SH;+0:2].[*:3]-[SH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1.[*:3]-[S;H0;+0:4]-[S;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Discovery and characterization of a Coenzyme A disulfide reductase from Pyrococcus horikoshii. Implications for this disulfide metabolism of anaerobic hyperthermophiles. | Harris DR, Ward DE, Feasel JM, Lancaster KM, Murphy RD, Mallet TC, Crane EJ 3rd | 2005 Mar | 15720393 |
| Coenzyme A-disulfide reductase from Staphylococcus aureus: evidence for asymmetric behavior on interaction with pyridine nucleotides. | Luba J, Charrier V, Claiborne A | 1999 Mar 2 | 10052943 |