EC number:1.8.1.15
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.8 Acting on a sulfur group of donors |
| 1.8.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.8.1.15 |
|---|---|
| Description: | Mycothione reductase. |
| Alternative Name: |
Mycothiol-disulfide reductase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.8.1.15 |
| BRENDA Enzyme Link: | BRENDA 1.8.1.15 |
| KEGG Enzyme Link: | KEGG1.8.1.15 |
| BioCyc Enzyme Link: | BioCyc 1.8.1.15 |
| ExPASy Enzyme Link: | ExPASy1.8.1.15 |
| EC2PDB Enzyme Link: | EC2PDB 1.8.1.15 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.8.1.15 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.8.1.15 |
| IntEnz Enzyme Link: | IntEnz 1.8.1.15 |
| MEDLINE Enzyme Link: | MEDLINE 1.8.1.15 |
| RHEA:12689 | 2 mycothiol + NAD(+) = H(+) + mycothione + NADH |
| RULE(radius=1) | [*:1]-[SH;+0:2].[*:3]-[SH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1.[*:3]-[S;H0;+0:4]-[S;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mycobacterium tuberculosis mycothione reductase: pH dependence of the kinetic parameters and kinetic isotope effects. | Patel MP, Blanchard JS | 2001 May 1 | 11318633 |
| Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase. | Patel MP, Blanchard JS | 1999 Sep 7 | 10512639 |
| RHEA:12685 | 2 mycothiol + NADP(+) = H(+) + mycothione + NADPH |
| RULE(radius=1) | [*:1]-[SH;+0:2].[*:3]-[SH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1.[*:3]-[S;H0;+0:4]-[S;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mycobacterium tuberculosis mycothione reductase: pH dependence of the kinetic parameters and kinetic isotope effects. | Patel MP, Blanchard JS | 2001 May 1 | 11318633 |
| Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase. | Patel MP, Blanchard JS | 1999 Sep 7 | 10512639 |