EC number:1.8.1.7
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.8 Acting on a sulfur group of donors |
| 1.8.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.8.1.7 | ||
|---|---|---|---|
| Description: | Glutathione-disulfide reductase. | ||
| Alternative Name: |
NADPH:oxidized-glutathione oxidoreductase. NADPH-GSSG reductase. NADPH-glutathione reductase. GSSG reductase. GSH reductase. Glutathione S-reductase. Glutathione reductase (NADPH). Glutathione reductase. | ||
| Prosite: | PDOC00073; | ||
| PDB: |
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| Cath: | 3.30.390.30; 3.50.50.60; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.8.1.7 |
| BRENDA Enzyme Link: | BRENDA 1.8.1.7 |
| KEGG Enzyme Link: | KEGG1.8.1.7 |
| BioCyc Enzyme Link: | BioCyc 1.8.1.7 |
| ExPASy Enzyme Link: | ExPASy1.8.1.7 |
| EC2PDB Enzyme Link: | EC2PDB 1.8.1.7 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.8.1.7 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.8.1.7 |
| IntEnz Enzyme Link: | IntEnz 1.8.1.7 |
| MEDLINE Enzyme Link: | MEDLINE 1.8.1.7 |
| RHEA:11740 | 2 glutathione + NADP(+) = glutathione disulfide + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[SH;+0:2].[*:3]-[SH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1.[*:1]-[S;H0;+0:2]-[S;H0;+0:4]-[*:3] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The catalytic mechanism of glutathione reductase as derived from x-ray diffraction analyses of reaction intermediates. | Pai EF, Schulz GE | 1983 Feb 10 | 6822532 |
| Refined structure of glutathione reductase at 1.54 A resolution. | Karplus PA, Schulz GE | 1987 Jun 5 | 3656429 |
| Substrate binding and catalysis by glutathione reductase as derived from refined enzyme: substrate crystal structures at 2 A resolution. | Karplus PA, Schulz GE | 1989 Nov 5 | 2585516 |
| The glutathione reductase GSR-1 determines stress tolerance and longevity in Caenorhabditis elegans. | Lüersen K, Stegehake D, Daniel J, Drescher M, Ajonina I, Ajonina C, Hertel P, Woltersdorf C, Liebau E | 2013 | 23593298 |
| Human erythrocyte glutathione reductase: chemical mechanism and structure of the transition state for hydride transfer. | Sweet WL, Blanchard JS | 1991 Sep 3 | 1888731 |
| Catalytic cycle of human glutathione reductase near 1 A resolution. | Berkholz DS, Faber HR, Savvides SN, Karplus PA | 2008 Oct 3 | 18638483 |
| Purification and characterization of glutathione reductase from Rhodospirillum rubrum. | Libreros-Minotta CA, Pardo JP, Mendoza-Hernández G, Rendón JL | 1992 Oct | 1524433 |
| Kinetic characterization of glutathione reductase from the malarial parasite Plasmodium falciparum. Comparison with the human enzyme. | Bohme CC, Arscott LD, Becker K, Schirmer RH, Williams CH Jr | 2000 Dec 1 | 10969088 |