EC number:1.8.1.8
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.8 Acting on a sulfur group of donors |
| 1.8.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.8.1.8 |
|---|---|
| Description: | Protein-disulfide reductase. |
| Alternative Name: |
Protein disulfide reductase. Insulin-glutathione transhydrogenase. Disulfide reductase. |
| Cath: | 2.20.28.140; 3.40.30.10; 2.60.40.1250; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.8.1.8 |
| BRENDA Enzyme Link: | BRENDA 1.8.1.8 |
| KEGG Enzyme Link: | KEGG1.8.1.8 |
| BioCyc Enzyme Link: | BioCyc 1.8.1.8 |
| ExPASy Enzyme Link: | ExPASy1.8.1.8 |
| EC2PDB Enzyme Link: | EC2PDB 1.8.1.8 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.8.1.8 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.8.1.8 |
| IntEnz Enzyme Link: | IntEnz 1.8.1.8 |
| MEDLINE Enzyme Link: | MEDLINE 1.8.1.8 |
| RHEA:18753 | [protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[SH;+0:2].[*:3]-[SH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1.[*:1]-[S;H0;+0:2]-[S;H0;+0:4]-[*:3] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning and characterization of the nucleoredoxin gene that encodes a novel nuclear protein related to thioredoxin. | Kurooka H, Kato K, Minoguchi S, Takahashi Y, Ikeda J, Habu S, Osawa N, Buchberg AM, Moriwaki K, Shisa H, Honjo T | 1997 Feb 1 | 9119370 |
| A protein disulphide reductase from pea seeds. | HATCH MD, TURNER JF | 1960 Sep | 13712218 |
| RHEA:18749 | [protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) + NADH |
| RULE(radius=1) | [*:1]-[SH;+0:2].[*:3]-[SH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1.[*:1]-[S;H0;+0:2]-[S;H0;+0:4]-[*:3] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning and characterization of the nucleoredoxin gene that encodes a novel nuclear protein related to thioredoxin. | Kurooka H, Kato K, Minoguchi S, Takahashi Y, Ikeda J, Habu S, Osawa N, Buchberg AM, Moriwaki K, Shisa H, Honjo T | 1997 Feb 1 | 9119370 |
| A protein disulphide reductase from pea seeds. | HATCH MD, TURNER JF | 1960 Sep | 13712218 |