EC number:2.1.1.148
| ID: | 2.1.1.148 |
|---|---|
| Description: | Thymidylate synthase (FAD). |
| Alternative Name: |
Flavin dependent thymidylate synthase. FDTS. |
| Cath: | 1.10.287.1780; 1.10.287.1790; 1.20.5.30; 1.20.5.3070; 3.30.1360.170; 3.30.70.3180; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.148 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.148 |
| KEGG Enzyme Link: | KEGG2.1.1.148 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.148 |
| ExPASy Enzyme Link: | ExPASy2.1.1.148 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.148 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.148 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.148 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.148 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.148 |
EC number:2.1.1.148
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:29043 | (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[*:3]-[*:4]-[N;H0;+0:5](-[*:6])-[CH2;+0:7]-1.[*:8]-[N;H0;+0:9]1-[CH;+0:10]=[C;H0;+0:11](-[*:12])-[CH2;+0:13]-[CH;+0:14]=[CH;+0:15]-1.[*:16]:[cH;+0:17]:[*:18].[H+;H0:19]>>[*:1]-[NH;+0:2]-[*:3]-[*:4]-[NH;+0:5]-[*:6].[*:8]-[n+;H0:9]1:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:[cH;+0:14]:[cH;+0:15]:1.[*:16]:[c;H0;+0:17](:[*:18])-[CH3;+0:7] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Flavin-dependent thymidylate synthase: a novel pathway towards thymine. | Koehn EM, Kohen A | 2010 Jan 1 | 19643076 |
| An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene. | Koehn EM, Fleischmann T, Conrad JA, Palfey BA, Lesley SA, Mathews II, Kohen A | 2009 Apr 16 | 19370033 |