EC number:2.1.1.180

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.180
Description:16S rRNA (adenine(1408)-N(1))-methyltransferase.
Cath: 3.40.50.150;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.180
BRENDA Enzyme Link: BRENDA 2.1.1.180
KEGG Enzyme Link: KEGG2.1.1.180
BioCyc Enzyme Link: BioCyc 2.1.1.180
ExPASy Enzyme Link: ExPASy2.1.1.180
EC2PDB Enzyme Link: EC2PDB 2.1.1.180
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.180
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.180
IntEnz Enzyme Link: IntEnz 2.1.1.180
MEDLINE Enzyme Link: MEDLINE 2.1.1.180

EC number:2.1.1.180

MSA:

2.1.1.180;
Phylogenetic Tree:

2.1.1.180;
Uniprot:
M-CSA:
RHEA:42776 adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[S+;H0:2](-[*:3])-[CH3;+0:4].[*:5]:[c;H0;+0:6](-[NH2;+0:7]):[n;H0;+0:8]:[*:9]>>[*:1]-[S;H0;+0:2]-[*:3].[*:5]:[c;H0;+0:6](=[NH;+0:7]):[n;H0;+0:8](:[*:9])-[CH3;+0:4]
Reaction
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References

TitleAuthorsDatePubMed ID
Cloning of an aminoglycoside-resistance-encoding gene, kamC, from Saccharopolyspora hirsuta: comparison with kamB from Streptomyces tenebrarius.Holmes DJ, Drocourt D, Tiraby G, Cundliffe E1991 Jun 151840536
Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides.Wachino J, Shibayama K, Kurokawa H, Kimura K, Yamane K, Suzuki S, Shibata N, Ike Y, Arakawa Y2007 Dec17875999
Identification of a missing sequence and functionally important residues of 16S rRNA:m(1)A1408 methyltransferase KamB that causes bacterial resistance to aminoglycoside antibiotics.Koscinski L, Feder M, Bujnicki JM2007 May 1517495534